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Literature DB >> 16146331

Characterization of the human MDR1 gene.

Miklos Bodor¹, Edward J Kelly, Rodney J Ho.

Abstract

P-glycoprotein (Pgp), an ATP-dependent efflux transporter that protects the body from environmental toxins and xenobiotics, is encoded by the human MDR1 gene. Human MDR1 is located on chromosomal region 7q21. Although several different single nucleotide polymorphisms were shown to influence Pgp expression and activity, the reported length of the MDR1 gene in Genbank and other databases continues to evolve and varies between 6.3 kilobases (kb) and 210 kb. With DNA derived from human cell lines and tissues, we have characterized the MDR1 genomic sequence to be 209 kb.

Entities: Gene Species

Mesh：

Substances：
DNA

Year: 2005 PMID： 16146331 PMCID： PMC2751491 DOI： 10.1208/aapsj070101

Source DB: PubMed Journal: AAPS J ISSN： 1550-7416 Impact factor: 4.009

13 in total

1. Evidence that natural killer cells express mini P-glycoproteins but not classic 170 kDa P-glycoprotein.

Authors: C Trambas; Z Wang; M Cianfriglia; G Woods
Journal: Br J Haematol Date: 2001-07 Impact factor: 6.998

2. Transcriptional regulation of the human MDR1 gene at the level of the inverted MED-1 promoter region.

Authors: Stephane Labialle; Landry Gayet; Eric Marthinet; Dominique Rigal; Loris G Baggetto
Journal: Ann N Y Acad Sci Date: 2002-11 Impact factor: 5.691

3. The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

Authors: K Ueda; D P Clark; C J Chen; I B Roninson; M M Gottesman; I Pastan
Journal: J Biol Chem Date: 1987-01-15 Impact factor: 5.157

Review 4. Biochemistry of multidrug resistance mediated by the multidrug transporter.

Authors: M M Gottesman; I Pastan
Journal: Annu Rev Biochem Date: 1993 Impact factor: 23.643

Review 5. A family of drug transporters: the multidrug resistance-associated proteins.

Authors: P Borst; R Evers; M Kool; J Wijnholds
Journal: J Natl Cancer Inst Date: 2000-08-16 Impact factor: 13.506

6. Human P-glycoprotein transports cyclosporin A and FK506.

Authors: T Saeki; K Ueda; Y Tanigawara; R Hori; T Komano
Journal: J Biol Chem Date: 1993-03-25 Impact factor: 5.157

Review 7. Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs.

Authors: Toshiyuki Sakaeda; Tsutomu Nakamura; Katsuhiko Okumura
Journal: Pharmacogenomics Date: 2003-07 Impact factor: 2.533

8. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.

Authors: K Ueda; M M Cornwell; M M Gottesman; I Pastan; I B Roninson; V Ling; J R Riordan
Journal: Biochem Biophys Res Commun Date: 1986-12-30 Impact factor: 3.575

Review 9. The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function.

Authors: Erica L Woodahl; Rodney J Y Ho
Journal: Curr Drug Metab Date: 2004-02 Impact factor: 3.731

10. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

Authors: K Ueda; N Okamura; M Hirai; Y Tanigawara; T Saeki; N Kioka; T Komano; R Hori
Journal: J Biol Chem Date: 1992-12-05 Impact factor: 5.157

42 in total

1. MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies.

Authors: Xiaojing Sheng; Limei Zhang; Na Tong; Dewei Luo; Meilin Wang; Min Xu; Zhengdong Zhang
Journal: Mol Biol Rep Date: 2012-02-04 Impact factor: 2.316

2. Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters.

Authors: Julie Bertrand; Emmanuelle Comets; France Mentre
Journal: J Biopharm Stat Date: 2008 Impact factor: 1.051

10. Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populations.

Authors: Rebekah L Benish; Benigno Rodriguez; Peter A Zimmerman; Rajeev K Mehlotra
Journal: Infect Genet Evol Date: 2009-10-09 Impact factor: 3.342

Characterization of the human MDR1 gene.

1. Evidence that natural killer cells express mini P-glycoproteins but not classic 170 kDa P-glycoprotein.

2. Transcriptional regulation of the human MDR1 gene at the level of the inverted MED-1 promoter region.

3. The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

Review 4. Biochemistry of multidrug resistance mediated by the multidrug transporter.

Review 5. A family of drug transporters: the multidrug resistance-associated proteins.

6. Human P-glycoprotein transports cyclosporin A and FK506.

Review 7. Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs.

8. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.

Review 9. The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function.

10. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1. MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies.

2. Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters.

3. ABCB1 polymorphisms correlate with susceptibility to adult acute leukemia and response to high-dose methotrexate.

4. XRCC1 genetic polymorphism acts a potential biomarker for lung cancer.

5. The role of Multidrug Resistance-1 (MDR1) variants in response to atorvastatin among Jordanians.

6. Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).

Review 7. Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation.

Review 8. CTLA-4 and MDR1 polymorphisms increase the risk for ulcerative colitis: A meta-analysis.

9. MDR1 polymorphisms have an impact on the prognosis of Chinese diffuse large B cell lymphoma patients.

10. Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populations.