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Literature DB >> 25273678

ABCB1 C3435T polymorphism influences the risk for Alzheimer's disease.

Ágnes Fehér¹, Anna Juhász, Magdolna Pákáski, János Kálmán, Zoltán Janka.

Abstract

To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer's disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case-control sample (234 AD patients, 225 controls). Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. Haplotype analyses indicated three nominally significant associations which were lost after applying multiple test correction.

Entities: Disease Gene Mutation Species

Mesh：

Substances：

Year: 2014 PMID： 25273678 DOI： 10.1007/s12031-014-0427-z

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

25 in total

1. Haploview: analysis and visualization of LD and haplotype maps.

Authors: J C Barrett; B Fry; J Maller; M J Daly
Journal: Bioinformatics Date: 2004-08-05 Impact factor: 6.937

Review 2. Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease.

Authors: Jens Pahnke; Olaf Wolkenhauer; Markus Krohn; Lary C Walker
Journal: Curr Alzheimer Res Date: 2008-08 Impact factor: 3.498

3. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

Authors: I Cascorbi; T Gerloff; A Johne; C Meisel; S Hoffmeyer; M Schwab; E Schaeffeler; M Eichelbaum; U Brinkmann; I Roots
Journal: Clin Pharmacol Ther Date: 2001-03 Impact factor: 6.875

4. Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease.

Authors: Kuang-Den Chen; Po-Tsung Chang; Yueh-Hsin Ping; Hsin-Chen Lee; Chin-Wei Yeh; Pei-Ning Wang
Journal: Neurobiol Dis Date: 2011-06-06 Impact factor: 5.996

5. Genetic variability and haplotype profile of MDR1 (ABCB1) in Roma and Hungarian population samples with a review of the literature.

Authors: Csilla Sipeky; Veronika Csongei; Luca Jaromi; Eniko Safrany; Anita Maasz; Istvan Takacs; Judit Beres; Lajos Fodor; Melinda Szabo; Bela Melegh
Journal: Drug Metab Pharmacokinet Date: 2010-12-17 Impact factor: 3.614

6. beta-Amyloid efflux mediated by p-glycoprotein.

Authors: F C Lam; R Liu; P Lu; A B Shapiro; J M Renoir; F J Sharom; P B Reiner
Journal: J Neurochem Date: 2001-02 Impact factor: 5.372

7. ABCB1 genotype and CSF beta-amyloid in Alzheimer disease.

Authors: R Kohen; J B Shofer; O Korvatska; E C Petrie; L Y Wang; G D Schellenberg; E R Peskind; C W Wilkinson
Journal: J Geriatr Psychiatry Neurol Date: 2011-04-08 Impact factor: 2.680

8. Serum amyloid beta peptides in patients with dementia and age-matched non-demented controls as detected by surface-enhanced laser desorption ionisation-time of flight mass spectrometry (SELDI-TOF MS).

Authors: Suzanne V Frankfort; Jos P C M van Campen; Linda R Tulner; Jos H Beijnen
Journal: Curr Clin Pharmacol Date: 2008-09

9. MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier.

Authors: Diana Kuhnke; Gabriele Jedlitschky; Markus Grube; Markus Krohn; Mathias Jucker; Igor Mosyagin; Ingolf Cascorbi; Lary C Walker; Heyo K Kroemer; Rolf W Warzok; Silke Vogelgesang
Journal: Brain Pathol Date: 2007-07-04 Impact factor: 6.508

ABCB1 C3435T polymorphism influences the risk for Alzheimer's disease.

1. Haploview: analysis and visualization of LD and haplotype maps.

Review 2. Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease.

3. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

4. Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease.

5. Genetic variability and haplotype profile of MDR1 (ABCB1) in Roma and Hungarian population samples with a review of the literature.

6. beta-Amyloid efflux mediated by p-glycoprotein.

7. ABCB1 genotype and CSF beta-amyloid in Alzheimer disease.

8. Serum amyloid beta peptides in patients with dementia and age-matched non-demented controls as detected by surface-enhanced laser desorption ionisation-time of flight mass spectrometry (SELDI-TOF MS).

9. MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier.

10. ABC Transporters and the Alzheimer's Disease Enigma.

Review 1. P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease.

2. Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary.

3. Biallelic mutations in ABCB1 display recurrent reversible encephalopathy.

4. Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis.