BACKGROUND AND AIM: Recent research suggests that low vitamin D may be associated with cardiovascular disease (CVD). METHODS AND RESULTS: We prospectively evaluated the association of dietary plus supplemental vitamin D intake and serum 25(OH) vitamin D with CVD incidence in the Osteoporotic Fractures in Men (MrOS) Study. Vitamin D intake was measured using a food frequency questionnaire and self-reported supplemental intake in 3094 men (mean age 76.4 years). From a subset of this population, we measured 25(OH) vitamin D in 813 men. Median 25(OH) vitamin D was 25.3 ng/mL. During a median follow-up of 4.4 years, there were 472 CVD cases, including 371 from coronary heart disease (CHD) and 101 from cerebrovascular attack (CVA). In the 25(OH) vitamin D sub-cohort, there were 140 cases of CVD including 115 from CHD and 25 from CVA. We used a Cox proportional hazards regression to calculate hazard ratios (HR) for CVD by vitamin D quartile. After adjusting for age, season, and standard CVD risk factors, the lowest quartile of 25(OH) vitamin D (HR, 1.18; 95% CI, 0.69-2.03) and vitamin D intake (HR, 0.76; 95% CI, 0.56-1.04) were not significantly associated with CVD incidence, compared to the highest vitamin D quartiles. When 25(OH) vitamin D was further analyzed by sufficiency (≥30 ng/mL), insufficiency (≥15-29.9 ng/mL), and deficiency (<15 ng/mL), vitamin D deficiency was not significantly associated with CVD incidence compared to sufficiency (HR 1.34; 95% CI 0.65-2.77). CONCLUSION: Vitamin D intake and serum 25(OH) vitamin D were not associated with CVD risk.
BACKGROUND AND AIM: Recent research suggests that low vitamin D may be associated with cardiovascular disease (CVD). METHODS AND RESULTS: We prospectively evaluated the association of dietary plus supplemental vitamin D intake and serum 25(OH) vitamin D with CVD incidence in the Osteoporotic Fractures in Men (MrOS) Study. Vitamin D intake was measured using a food frequency questionnaire and self-reported supplemental intake in 3094 men (mean age 76.4 years). From a subset of this population, we measured 25(OH) vitamin D in 813 men. Median 25(OH) vitamin D was 25.3 ng/mL. During a median follow-up of 4.4 years, there were 472 CVD cases, including 371 from coronary heart disease (CHD) and 101 from cerebrovascular attack (CVA). In the 25(OH) vitamin D sub-cohort, there were 140 cases of CVD including 115 from CHD and 25 from CVA. We used a Cox proportional hazards regression to calculate hazard ratios (HR) for CVD by vitamin D quartile. After adjusting for age, season, and standard CVD risk factors, the lowest quartile of 25(OH) vitamin D (HR, 1.18; 95% CI, 0.69-2.03) and vitamin D intake (HR, 0.76; 95% CI, 0.56-1.04) were not significantly associated with CVD incidence, compared to the highest vitamin D quartiles. When 25(OH) vitamin D was further analyzed by sufficiency (≥30 ng/mL), insufficiency (≥15-29.9 ng/mL), and deficiency (<15 ng/mL), vitamin D deficiency was not significantly associated with CVD incidence compared to sufficiency (HR 1.34; 95% CI 0.65-2.77). CONCLUSION:Vitamin D intake and serum 25(OH) vitamin D were not associated with CVD risk.
Authors: Annamari Kilkkinen; Paul Knekt; Antti Aro; Harri Rissanen; Jukka Marniemi; Markku Heliövaara; Olli Impivaara; Antti Reunanen Journal: Am J Epidemiol Date: 2009-09-17 Impact factor: 4.897
Authors: Harald Dobnig; Stefan Pilz; Hubert Scharnagl; Wilfried Renner; Ursula Seelhorst; Britta Wellnitz; Jürgen Kinkeldei; Bernhard O Boehm; Gisela Weihrauch; Winfried Maerz Journal: Arch Intern Med Date: 2008-06-23
Authors: R D Semba; D K Houston; S Bandinelli; K Sun; A Cherubini; A R Cappola; J M Guralnik; L Ferrucci Journal: Eur J Clin Nutr Date: 2009-12-02 Impact factor: 4.016
Authors: Lu Wang; Yiqing Song; Joann E Manson; Stefan Pilz; Winfried März; Karl Michaëlsson; Annamari Lundqvist; Simerjot K Jassal; Elizabeth Barrett-Connor; Cuilin Zhang; Charles B Eaton; Heidi T May; Jeffrey L Anderson; Howard D Sesso Journal: Circ Cardiovasc Qual Outcomes Date: 2012-11-13
Authors: Archna Bajaj; Katie L Stone; Katherine Peters; Neeta Parimi; Elizabeth Barrett-Connor; Doug Bauer; Peggy M Cawthon; Kristine E Ensrud; Andrew R Hoffman; Eric Orwoll; Eva S Schernhammer Journal: J Clin Endocrinol Metab Date: 2014-03-26 Impact factor: 5.958
Authors: Janet Maxwell Roseland; Kristine Y Patterson; Karen W Andrews; Katherine M Phillips; Melissa M Phillips; Pamela R Pehrsson; Guy L Dufresne; Jette Jakobsen; Pavel A Gusev; Sushma Savarala; Quynhanh V Nguyen; Andrew J Makowski; Chad R Scheuerell; Guillaume P Larouche; Stephen A Wise; James M Harnly; Juhi R Williams; Joseph M Betz; Christine L Taylor Journal: J Agric Food Chem Date: 2016-04-15 Impact factor: 5.279