PURPOSE: To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian. METHODS: Forty-four eyes of 22 healthy subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain-optical coherence tomography (SD-OCT) was used to assess the topographic thickness of the epithelium and the Bowman's layer across the cornea. Thicknesses at five locations, including the center, midperiphery, and periphery close to the limbus, on both the nasal and the temporal sides along the horizontal meridian, were analyzed. RESULTS: Mean epithelial thickness at the central cornea was 52.5 ± 2.4 μm. It increased gradually from the center to the periphery (P < 0.001). There was no significant difference between the nasal side and the temporal side for epithelial thickness. The central Bowman's layer thickness was 17.7 ± 1.6 μm, and it remained constant from the center to the midperiphery (P > 0.05). However, thicknesses at the nasal and temporal periphery, 20.0 ± 1.9 μm and 19.8 ± 2.2 μm, respectively, were significantly greater than the central and midperipheral thicknesses (P < 0.001). Nasal and temporal thicknesses were similar on either side of the center. CONCLUSIONS: The epithelium and the Bowman's layer were not evenly distributed across the horizontal meridian of the cornea. SD-OCT provided useful information about topographic thickness of the different corneal layers in vivo.
PURPOSE: To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian. METHODS: Forty-four eyes of 22 healthy subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain-optical coherence tomography (SD-OCT) was used to assess the topographic thickness of the epithelium and the Bowman's layer across the cornea. Thicknesses at five locations, including the center, midperiphery, and periphery close to the limbus, on both the nasal and the temporal sides along the horizontal meridian, were analyzed. RESULTS: Mean epithelial thickness at the central cornea was 52.5 ± 2.4 μm. It increased gradually from the center to the periphery (P < 0.001). There was no significant difference between the nasal side and the temporal side for epithelial thickness. The central Bowman's layer thickness was 17.7 ± 1.6 μm, and it remained constant from the center to the midperiphery (P > 0.05). However, thicknesses at the nasal and temporal periphery, 20.0 ± 1.9 μm and 19.8 ± 2.2 μm, respectively, were significantly greater than the central and midperipheral thicknesses (P < 0.001). Nasal and temporal thicknesses were similar on either side of the center. CONCLUSIONS: The epithelium and the Bowman's layer were not evenly distributed across the horizontal meridian of the cornea. SD-OCT provided useful information about topographic thickness of the different corneal layers in vivo.
Authors: Julie A Last; Sara M Thomasy; Christopher R Croasdale; Paul Russell; Christopher J Murphy Journal: Micron Date: 2012-02-25 Impact factor: 2.251
Authors: Taher K Eleiwa; Amr Elsawy; Zeba A Syed; Vatookarn Roongpoovapatr; Ahmed M Sayed; Sonia H Yoo; Mohamed Abou Shousha Journal: Curr Eye Res Date: 2020-02-16 Impact factor: 2.424
Authors: Mohamed Abou Shousha; Victor L Perez; Ana Paula Fraga Santini Canto; Pravin K Vaddavalli; Fouad E Sayyad; Florence Cabot; William J Feuer; Jianhua Wang; Sonia H Yoo Journal: Ophthalmology Date: 2014-01-24 Impact factor: 12.079
Authors: Mohamed Abou Shousha; Carol L Karp; Ana Paula Canto; Kelly Hodson; Patrick Oellers; Andrew A Kao; Brett Bielory; Jared Matthews; Sander R Dubovy; Victor L Perez; Jianhua Wang Journal: Ophthalmology Date: 2013-01-21 Impact factor: 12.079