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Literature DB >> 214575

Recombinants between herpes simplex virus types 1 and 2: analyses of genome structures and expression of immediate early polypeptides.

V G Preston, A J Davison, H S Marsden, M C Timbury, J H Subak-Sharpe, N M Wilkie.

Abstract

Recombinants between temperature-sensitive mutants of herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) were constructed. Using restriction endonucleases, we analyzed the genome composition of 17 intertypic recombinants and detected crossovers in every region of the genome. The virion DNA of one recombinant appeared to be largely "frozen" in two of the four possible genome arrangements of HSV. Knowledge of the genome structures of recombinants enabled us to physically map immediate early polypeptides. We present evidence that the immediate early polypeptide Vmw IE 110 of HSV-1 and its functionally equivalent polypeptide, Vmw IE 118, of HSV-2 may map in the repetitive sequences bounding the long unique region of HSV.

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Year: 1978 PMID： 214575 PMCID： PMC354299

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

33 in total

1. Comparative analysis of polypeptides induced by type 1 and type 2 strains of herpes simplex virus.

Authors: K L Powell; R Mirkovic; R J Courtney
Journal: Intervirology Date: 1977 Impact factor: 1.763

2. The physical locations of structural genes in adenovirus DNA.

Authors: T Grodzicker; C Anderson; J Sambrook; M B Mathews
Journal: Virology Date: 1977-07-01 Impact factor: 3.616

3. Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome.

Authors: J B Clements; R J Watson; N M Wilkie
Journal: Cell Date: 1977-09 Impact factor: 41.582

4. Anatomy of herpes simplex virus DNA VII. alpha-RNA is homologous to noncontiguous sites in both the L and S components of viral DNA.

Authors: P C Jones; G S Hayward; B Roizman
Journal: J Virol Date: 1977-01 Impact factor: 5.103

5. A partial denaturation map of herpes simplex virus type 1 DNA: evidence for inversions of the unique DNA regions.

Authors: H Delius; J B Clements
Journal: J Gen Virol Date: 1976-10 Impact factor: 3.891

6. Analysis of herpesvirus DNA substructure by means of restriction endonucleases.

Authors: J B Clements; R Cortini; N M Wilkie
Journal: J Gen Virol Date: 1976-02 Impact factor: 3.891

7. Sequence arrangement in herpes simplex virus type 1 DNA: identification of terminal fragments in restriction endonuclease digests and evidence for inversions in redundant and unique sequences.

Authors: N M Wilkie; R Cortini
Journal: J Virol Date: 1976-10 Impact factor: 5.103

8. Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.

Authors: Y Aloni; R Dhar; O Laub; M Horowitz; G Khoury
Journal: Proc Natl Acad Sci U S A Date: 1977-09 Impact factor: 11.205

9. Physical maps for Herpes simplex virus type 1 DNA for restriction endonucleases Hind III, Hpa-1, and X. bad.

Authors: N M Wilkie
Journal: J Virol Date: 1976-10 Impact factor: 5.103

10. Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Authors: S M Berget; C Moore; P A Sharp
Journal: Proc Natl Acad Sci U S A Date: 1977-08 Impact factor: 11.205

66 in total

1. Temperature-dependent conformational changes in herpes simplex virus ICP4 that affect transcription activation.

Authors: Peter Compel; Neal A DeLuca
Journal: J Virol Date: 2003-03 Impact factor: 5.103

2. Orientation of herpes simplex virus type 1 immediate early mRNA's.

Authors: J B Clements; J McLauchlan; D J McGeoch
Journal: Nucleic Acids Res Date: 1979-09-11 Impact factor: 16.971

3. Separation and characterization of herpes simplex virus type 1 immediate-early mRNA's.

Authors: R J Watson; C M Preston; J B Clements
Journal: J Virol Date: 1979-07 Impact factor: 5.103

4. Origin of two different classes of defective HSV-1 Angelotti DNA.

Authors: H C Kaerner; I B Maichle; A Ott; C H Schröder
Journal: Nucleic Acids Res Date: 1979-04 Impact factor: 16.971

5. Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis.

Authors: C A Wu; N J Nelson; D J McGeoch; M D Challberg
Journal: J Virol Date: 1988-02 Impact factor: 5.103

6. Properties of cells carrying the herpes simplex virus type 2 thymidine kinase gene: mechanisms of reversion to a thymidine kinase-negative phenotype.

Authors: K F Bastow; G Darby; P Wildy; A C Minson
Journal: J Virol Date: 1980-12 Impact factor: 5.103

7. ICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated.

Authors: J A Blaho; B Roizman
Journal: J Virol Date: 1991-07 Impact factor: 5.103

8. In vitro transcription and translation of proteins encoded by the BamHI-B genomic fragment of herpes simplex virus-1.

Authors: M Moyal; Y Asher; G Darai; A Rösen-Wolff; A Vafai; Y Becker
Journal: Virus Genes Date: 1991-04 Impact factor: 2.332

9. Recombination and linkage between structural and regulatory genes of herpes simplex virus type 1: study of the functional organization of the genome.

Authors: R W Honess; A Buchan; I W Halliburton; D H Watson
Journal: J Virol Date: 1980-06 Impact factor: 5.103

10. Control of expression of the herpes simplex virus-induced deoxypyrimidine triphosphatase in cells infected with mutants of herpes simplex virus types 1 and 2 and intertypic recombinants.

Authors: F Wohlrab; B K Garrett; B Francke
Journal: J Virol Date: 1982-09 Impact factor: 5.103