Literature DB >> 2145213

Elevated synovial tissue concentration of the common acute lymphoblastic leukaemia antigen (CALLA)-associated neutral endopeptidase (3.4.24.11) in human chronic arthritis.

S P Sreedharan1, E J Goetzl, B Malfroy.   

Abstract

The cell-surface neutral endopeptidase 3.4.24.11 (NEP) activity of the common acute lymphoblastic leukaemia antigen (CALLA) cleaves diverse peptide mediators at specific sites and it has been postulated that it regulates immune responses. The concentration of NEP was quantified in detergent extracts of synovial tissues by the percentage hydrolysis of [3H-D-Ala]-Leu enkephalin/hr/100 mg of tissue. The synovial tissue concentration of NEP was higher in all patients with rheumatoid arthritis (n = 7; group mean +/- SD = 29.4 +/- 20.2%), and was higher with degenerative joint disease (n = 6 of 8; group mean +/- SD = 11.9 +/- 10.4%) than with traumatic arthropathy (n = 3; 1.1 +/- 0.7%). The lack of direct relationship between synovial tissue NEP concentration and leukocytic infiltration suggests that the cellular source of NEP may be synoviocytes or fibroblasts, and that NEP may have distinctive pathogenetic roles in human arthritis.

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Year:  1990        PMID： 2145213      PMCID： PMC1384235     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  10 in total

1.  Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).

Authors:  B Malfroy; W J Kuang; P H Seeburg; A J Mason; P R Schofield
Journal:  FEBS Lett       Date:  1988-02-29       Impact factor: 4.124

2.  Selective inhibition of antigen presentation to cloned T cells by protease inhibitors.

Authors:  J Puri; Y Factorovich
Journal:  J Immunol       Date:  1988-11-15       Impact factor: 5.422

3.  Phorbol diesters regulate expression of the membrane neutral metalloendopeptidase (EC 3.4.24.11) in rabbit synovial fibroblasts and mammary epithelial cells.

Authors:  Z Werb; E J Clark
Journal:  J Biol Chem       Date:  1989-06-05       Impact factor: 5.157

4.  Function of neutral endopeptidase on the cell membrane of human neutrophils.

Authors:  R G Painter; R Dukes; J Sullivan; R Carter; E G Erdös; A R Johnson
Journal:  J Biol Chem       Date:  1988-07-05       Impact factor: 5.157

5.  Enkephalin dipeptidyl carboxypeptidase (enkephalinase) activity: selective radioassay, properties, and regional distribution in human brain.

Authors:  C Llorens; B Malfroy; J C Schwartz; G Gacel; B P Roques; J Roy; J L Morgat; F Javoy-Agid; Y Agid
Journal:  J Neurochem       Date:  1982-10       Impact factor: 5.372

6.  Neutral endopeptidase-24.11 (enkephalinase). Biosynthesis and localization in human fibroblasts.

Authors:  G Lorkowski; J E Zijderhand-Bleekemolen; E G Erdös; K von Figura; A Hasilik
Journal:  Biochem J       Date:  1987-12-01       Impact factor: 3.857

7.  Effect of human endopeptidase 24.11 ("enkephalinase") on IL-1-induced thymocyte proliferation activity.

Authors:  M E Pierart; T Najdovski; T E Appelboom; M M Deschodt-Lanckman
Journal:  J Immunol       Date:  1988-06-01       Impact factor: 5.422

Review 8.  Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones.

Authors:  E G Erdös; R A Skidgel
Journal:  FASEB J       Date:  1989-02       Impact factor: 5.191

9.  Common acute lymphoblastic leukemia antigen expressed on leukemia and melanoma cell lines has neutral endopeptidase activity.

Authors:  C V Jongeneel; E J Quackenbush; P Ronco; P Verroust; S Carrel; M Letarte
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

10.  Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis.

Authors:  M A Shipp; J Vijayaraghavan; E V Schmidt; E L Masteller; L D'Adamio; L B Hersh; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205
  10 in total
  5 in total

Review 1.  Innervation of the synovium.

Authors:  P I Mapp
Journal:  Ann Rheum Dis       Date:  1995-05       Impact factor: 19.103

2.  Cultured human synovial fibroblasts rapidly metabolize kinins and neuropeptides.

Authors:  J M Bathon; D Proud; S Mizutani; P E Ward
Journal:  J Clin Invest       Date:  1992-09       Impact factor: 14.808

3.  Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation?

Authors:  M Matucci-Cerinic; A Lombardi; G Leoncini; A Pignone; L Sacerdoti; M G Spillantini; G Partsch
Journal:  Rheumatol Int       Date:  1993       Impact factor: 2.631

4.  Neuropeptide degrading enzymes in normal and inflamed human synovium.

Authors:  D A Walsh; P I Mapp; J Wharton; J M Polak; D R Blake
Journal:  Am J Pathol       Date:  1993-05       Impact factor: 4.307

5.  Neprilysin levels in plasma and synovial fluid of juvenile idiopathic arthritis patients.

Authors:  Gabriele Simonini; Chiara Azzari; Anna Maria Grazia Gelli; Teresa Giani; Giovanni Battista Calabri; Gigliola Leoncini; Angela Del Rosso; Sergio Generini; Rolando Cimaz; Marco Matucci Cerinic; Fernanda Falcini
Journal:  Rheumatol Int       Date:  2004-03-03       Impact factor: 2.631
  5 in total

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