Literature DB >> 3162217

Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).

B Malfroy1, W J Kuang, P H Seeburg, A J Mason, P R Schofield.   

Abstract

We have isolated a cDNA clone encoding human enkephalinase (neutral endopeptidase, EC 3.4.24.11) in a lambda gt10 library from human placenta, and present the complete 742 amino acid sequence of human enkephalinase. The human enzyme displays a high homology with rat and rabbit enkephalinase. Like the rat and rabbit enzyme, human enkephalinase contains a single N-terminal transmembrane region and is likely to be inserted through cell membranes with the majority of protein, including its carboxy-terminus, located extracellularly.

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Year:  1988        PMID： 3162217     DOI： 10.1016/0014-5793(88)80828-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  51 in total

1.  Soluble enkephalin-degrading enzymes released by lymphomic and erythroleukaemic cell lines.

Authors:  M Marini; A Urbani; L Bongiorno; L G Roda
Journal:  Neurochem Res       Date:  1992-11       Impact factor: 3.996

2.  Secretion of a functional soluble form of neutral endopeptidase-24.11 from a baculovirus-infected insect cell line.

Authors:  F Fossiez; G Lemay; N Labonté; F Parmentier-Lesage; G Boileau; P Crine
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

Review 3.  Decreased neutral endopeptidases: possible role in inflammatory diseases of airways.

Authors:  J A Nadel
Journal:  Lung       Date:  1990       Impact factor: 2.584

4.  Effect of differentiation on the leucine enkephalin-degrading soluble enzymes released by the K562(S) cell line.

Authors:  M Marini; L Bongiorno; A Urbani; E Trani; L G Roda
Journal:  Neurochem Res       Date:  1997-12       Impact factor: 3.996

5.  Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs.

Authors:  H Kohrogi; J A Nadel; B Malfroy; C Gorman; R Bridenbaugh; J S Patton; D B Borson
Journal:  J Clin Invest       Date:  1989-09       Impact factor: 14.808

6.  The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes.

Authors:  D A Halliday; J D McNeil; W H Betts; R Scicchitano
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857

7.  Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.

Authors:  Catherine Rougeot; Michaël Messaoudi; Véronique Hermitte; Anne Gaëlle Rigault; Thierry Blisnick; Christophe Dugave; Didier Desor; François Rougeon
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-30       Impact factor: 11.205

8.  Metabolism of endothelin-1 and big endothelin-1 by recombinant neutral endopeptidase EC.3.4.24.11.

Authors:  Z A Abassi; E Golomb; R Bridenbaugh; H R Keiser
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

9.  Autocrine regulation of human sperm motility by tachykinins.

Authors:  Francisco M Pinto; Cristina G Ravina; Nerea Subiran; Antonio Cejudo-Román; Manuel Fernández-Sánchez; Jon Irazusta; Nicolas Garrido; Luz Candenas
Journal:  Reprod Biol Endocrinol       Date:  2010-08-26       Impact factor: 5.211

10.  Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis".

Authors:  M C Fournié-Zaluski; J M Soleilhac; S Turcaud; R Laï-Kuen; P Crine; A Beaumont; B P Roques
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205
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