| Literature DB >> 21443184 |
Hiroyuki Yamakoshi1, Kosuke Dodo, Masaya Okada, Jun Ando, Almar Palonpon, Katsumasa Fujita, Satoshi Kawata, Mikiko Sodeoka.
Abstract
Click-free imaging of the nuclear localization of an alkyne-tagged cell proliferation probe, EdU, in living cells was achieved for the first time by means of Raman microscopy. The alkyne tag shows an intense Raman band in a cellular Raman-silent region that is free of interference from endogenous molecules. This approach may eliminate the need for click reactions in the detection of alkyne-labeled molecules.Entities:
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Year: 2011 PMID： 21443184 DOI： 10.1021/ja108404p
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419