Literature DB >> 21440437

Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents.

Feng Ni1, Smitha Kota, Virginia Takahashi, A Donny Strosberg, John K Snyder.   

Abstract

New indoline alkaloid-type compounds which inhibit HCV production by infected hepatoma cells have been identified. These compounds, dimeric-type compounds of previously known inhibitors, display double digit nanomolar IC(50) and EC(50) values, with cytotoxicity CC(50) indexes higher than 36 μM, thus providing ample therapeutic windows for further development of HCV drugs.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21440437      PMCID： PMC3086078          DOI： 10.1016/j.bmcl.2011.03.014

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  34 in total

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Review 2.  Chemical control over protein-protein interactions: beyond inhibitors.

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Review 4.  A review of HCV protease inhibitors.

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Journal:  Curr Opin Investig Drugs       Date:  2009-08

5.  New small molecule inhibitors of hepatitis C virus.

Authors:  Wanguo Wei; Cuifang Cai; Smitha Kota; Virginia Takahashi; Feng Ni; A Donny Strosberg; John K Snyder
Journal:  Bioorg Med Chem Lett       Date:  2009-10-21       Impact factor: 2.823

Review 6.  Hepatitis C virus genetic variability in patients undergoing antiviral therapy.

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7.  Bisimidazoacridones and related compounds: new antineoplastic agents with high selectivity against colon tumors.

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8.  A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization.

Authors:  Smitha Kota; Louis Scampavia; Timothy Spicer; Aaron B Beeler; Virginia Takahashi; John K Snyder; John A Porco; Peter Hodder; Arthur Donny Strosberg
Journal:  Assay Drug Dev Technol       Date:  2010-02       Impact factor: 1.738

Review 9.  Genetic diversity and evolution of hepatitis C virus--15 years on.

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Journal:  J Gen Virol       Date:  2004-11       Impact factor: 3.891

10.  An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.

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  9 in total

1.  Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach.

Authors:  Claire Marie Filone; Erin N Hodges; Brian Honeyman; G Guy Bushkin; Karla Boyd; Andrew Platt; Feng Ni; Kyle Strom; Lisa Hensley; John K Snyder; John H Connor
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Journal:  N Engl J Med       Date:  2013-05-16       Impact factor: 91.245

3.  Direct binding of a hepatitis C virus inhibitor to the viral capsid protein.

Authors:  Smitha Kota; Virginia Takahashi; Feng Ni; John K Snyder; A Donny Strosberg
Journal:  PLoS One       Date:  2012-02-28       Impact factor: 3.240

4.  Access to pyrrolo-pyridines by gold-catalyzed hydroarylation of pyrroles tethered to terminal alkynes.

Authors:  Elena Borsini; Gianluigi Broggini; Andrea Fasana; Chiara Baldassarri; Angelo M Manzo; Alcide D Perboni
Journal:  Beilstein J Org Chem       Date:  2011-10-26       Impact factor: 2.883

Review 5.  Chronic Hepatitis C Infection in Children: Current Treatment and New Therapies.

Authors:  Andrew Lee; Jeremy Rajanayagam; Mona Abdel-Hady
Journal:  J Clin Transl Hepatol       Date:  2015-03-15

Review 6.  Double the Chemistry, Double the Fun: Structural Diversity and Biological Activity of Marine-Derived Diketopiperazine Dimers.

Authors:  Nelson G M Gomes; Renato B Pereira; Paula B Andrade; Patrícia Valentão
Journal:  Mar Drugs       Date:  2019-09-27       Impact factor: 5.118

Review 7.  Targeting the Virus Capsid as a Tool to Fight RNA Viruses.

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Journal:  Viruses       Date:  2022-01-18       Impact factor: 5.048

Review 8.  Hepatitis C virus core protein: Not just a nucleocapsid building block, but an immunity and inflammation modulator.

Authors:  Hemalatha Mani; Jui-Hung Yen; Hao-Jen Hsu; Chun-Chun Chang; Je-Wen Liou
Journal:  Tzu Chi Med J       Date:  2021-09-24

9.  High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.

Authors:  Michael J Wichroski; Jie Fang; Betsy J Eggers; Ronald E Rose; Charles E Mazzucco; Kevin A Pokornowski; Carl J Baldick; Monique N Anthony; Craig J Dowling; Lauren E Barber; John E Leet; Brett R Beno; Samuel W Gerritz; Michele L Agler; Mark I Cockett; Daniel J Tenney
Journal:  PLoS One       Date:  2012-08-06       Impact factor: 3.240
  9 in total

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