Hiroki Satoh1, Yasuaki Saijo, Reiko Kishi, Hiroyuki Tsutsui. 1. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan. h-satoh@imb.me-h.ne.jp
Abstract
OBJECTIVES: Cardiovascular morbidity and mortality are closely associated with hypertension, however, predictors of incident hypertension have not been fully established. We have conducted a study aimed at evaluating whether brachial-ankle pulse wave velocity (baPWV) is a predictor of incident hypertension. METHODS: The relation between baPWV, a noninvasive index of aortic stiffness, and incident hypertension was evaluated in a cohort of 2278 Japanese normotensive male subjects with a follow-up of 3 years. RESULTS: Of the 2278 study participants, 151 (6.6%) had incident hypertension during the follow-up. After adjustment for variables, including age, gender, body mass index (BMI), smoking habit, alcohol consumption, diabetes mellitus, hyperlipidemia, family history of hypertension, heart rate, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, and fasting plasma glucose, multiple logistic regression analysis revealed that baPWV was a significant and independent predictor of incident hypertension with an adjusted odds ratio 1.45 (95% confidence interval 1.17-1.79, P < 0.01). In addition, baPWV values >1380 cm/s indicated a high risk for incident hypertension. CONCLUSIONS: Among the Japanese normotensive male subjects participating in this study, BaPWV was a significant and independent predictor of incident hypertension. This result suggests that BaPWV could be a useful screening method to identify normotensive individuals who should be targeted for interventions aimed at preventing the incident hypertension.
OBJECTIVES: Cardiovascular morbidity and mortality are closely associated with hypertension, however, predictors of incident hypertension have not been fully established. We have conducted a study aimed at evaluating whether brachial-ankle pulse wave velocity (baPWV) is a predictor of incident hypertension. METHODS: The relation between baPWV, a noninvasive index of aortic stiffness, and incident hypertension was evaluated in a cohort of 2278 Japanese normotensive male subjects with a follow-up of 3 years. RESULTS: Of the 2278 study participants, 151 (6.6%) had incident hypertension during the follow-up. After adjustment for variables, including age, gender, body mass index (BMI), smoking habit, alcohol consumption, diabetes mellitus, hyperlipidemia, family history of hypertension, heart rate, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, and fasting plasma glucose, multiple logistic regression analysis revealed that baPWV was a significant and independent predictor of incident hypertension with an adjusted odds ratio 1.45 (95% confidence interval 1.17-1.79, P < 0.01). In addition, baPWV values >1380 cm/s indicated a high risk for incident hypertension. CONCLUSIONS: Among the Japanese normotensive male subjects participating in this study, BaPWV was a significant and independent predictor of incident hypertension. This result suggests that BaPWV could be a useful screening method to identify normotensive individuals who should be targeted for interventions aimed at preventing the incident hypertension.
Authors: R Asmar; A Benetos; J Topouchian; P Laurent; B Pannier; A M Brisac; R Target; B I Levy Journal: Hypertension Date: 1995-09 Impact factor: 10.190
Authors: Om Narayan; Kim H Parker; Justin E Davies; Alun D Hughes; Ian T Meredith; James D Cameron Journal: J Hypertens Date: 2017-10 Impact factor: 4.844
Authors: Alicia Saz-Lara; Rosa María Bruno; Iván Cavero-Redondo; Celia Álvarez-Bueno; Blanca Notario-Pacheco; Vicente Martínez-Vizcaíno Journal: Front Cardiovasc Med Date: 2022-02-11
Authors: Y Wang; J J Mu; L K Geng; D Wang; K Y Ren; T S Guo; C Chu; B Q Xie; F Q Liu; Z Y Yuan Journal: Braz J Med Biol Res Date: 2014-11-07 Impact factor: 2.590