Literature DB >> 21424918

[Intravitreal implants: drug carriers and carriers of hope?].

S Winterhalter1, P Ruokonen, K H van der Velden, U Pleyer, A M Joussen.   

Abstract

Immunosuppressive agents are used for the therapy of noninfectious uveitis if intraocular quiescence and freedom from recurrences are not achievable with oral steroids at a low dosage. Partially, severe side effects are tolerated to preserve visual acuity even if the disease is limited to the eyes. Because of this a therapy would be desirable which is highly effective, limited to the eyes and with few side effects. For this fluocinolone acetonide and dexamethasone drug delivery systems were developed. Dexamethasone implants were already approved for the therapy of retinal vein occlusions and are used successfully. Diabetic macular edema would be another possible indication for dexamethasone implants.

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Year:  2011        PMID: 21424918     DOI: 10.1007/s00347-010-2264-y

Source DB:  PubMed          Journal:  Ophthalmologe        ISSN: 0941-293X            Impact factor:   1.059


  15 in total

Review 1.  Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel.

Authors:  D A Jabs; J T Rosenbaum; C S Foster; G N Holland; G J Jaffe; J S Louie; R B Nussenblatt; E R Stiehm; H Tessler; R N Van Gelder; S M Whitcup; D Yocum
Journal:  Am J Ophthalmol       Date:  2000-10       Impact factor: 5.258

2.  Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study.

Authors:  David M Brown; Peter A Campochiaro; Rishi P Singh; Zhengrong Li; Sarah Gray; Namrata Saroj; Amy Chen Rundle; Roman G Rubio; Wendy Yee Murahashi
Journal:  Ophthalmology       Date:  2010-04-09       Impact factor: 12.079

3.  Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema.

Authors:  Julia A Haller; Baruch D Kuppermann; Mark S Blumenkranz; George A Williams; David V Weinberg; Connie Chou; Scott M Whitcup
Journal:  Arch Ophthalmol       Date:  2010-03

4.  Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.

Authors:  Baruch D Kuppermann; Mark S Blumenkranz; Julia A Haller; George A Williams; David V Weinberg; Connie Chou; Scott M Whitcup
Journal:  Arch Ophthalmol       Date:  2007-03

5.  Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion.

Authors:  Julia A Haller; Francesco Bandello; Rubens Belfort; Mark S Blumenkranz; Mark Gillies; Jeffrey Heier; Anat Loewenstein; Young-Hee Yoon; Marie-Louise Jacques; Jenny Jiao; Xiao-Yan Li; Scott M Whitcup
Journal:  Ophthalmology       Date:  2010-04-24       Impact factor: 12.079

Review 6.  New developments in corticosteroid therapy for uveitis.

Authors:  Simon R J Taylor; Hazlita Isa; Lavnish Joshi; Sue Lightman
Journal:  Ophthalmologica       Date:  2010-08-18       Impact factor: 3.250

Review 7.  Clinical review: Anti-TNFalpha therapies in uveitis: perspective on 5 years of clinical experience.

Authors:  Srilakshmi M Sharma; Achim R Nestel; Richard W J Lee; Andrew D Dick
Journal:  Ocul Immunol Inflamm       Date:  2009 Nov-Dec       Impact factor: 3.070

8.  Dexamethasone posterior-segment drug delivery system in the treatment of macular edema resulting from uveitis or Irvine-Gass syndrome.

Authors:  George A Williams; Julia A Haller; Baruch D Kuppermann; Mark S Blumenkranz; David V Weinberg; Connie Chou; Scott M Whitcup
Journal:  Am J Ophthalmol       Date:  2009-03-09       Impact factor: 5.258

9.  Evaluation of the retinal toxicity and pharmacokinetics of dexamethasone after intravitreal injection.

Authors:  H W Kwak; D J D'Amico
Journal:  Arch Ophthalmol       Date:  1992-02

10.  Evaluation of an intravitreal fluocinolone acetonide implant versus standard systemic therapy in noninfectious posterior uveitis.

Authors:  Carlos Pavesio; Manfred Zierhut; Khaled Bairi; Timothy L Comstock; Dale W Usner
Journal:  Ophthalmology       Date:  2010-01-15       Impact factor: 12.079

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  5 in total

1.  [Intermediate uveitis: guidelines of the German Ophthalmological Society and the Professional Association of German Ophthalmologists].

Authors:  F Mackensen; L Baydoun; J Garweg; A Heiligenhaus; T Hudde
Journal:  Ophthalmologe       Date:  2014-11       Impact factor: 1.059

Review 2.  [Guidelines nr. 24a intermediate uveitis].

Authors: 
Journal:  Ophthalmologe       Date:  2021-01       Impact factor: 1.059

3.  [Intravitreal dexamethasone implant for treatment of persistent postoperative macular edema after vitrectomy].

Authors:  L-O Hattenbach; C Kuhli-Hattenbach; C Springer; J Callizo; H Hoerauf
Journal:  Ophthalmologe       Date:  2016-07       Impact factor: 1.059

Review 4.  The therapeutic potential of intraocular depot steroid systems: developments aimed at prolonging duration of efficacy.

Authors:  Martin M Nentwich; Michael W Ulbig
Journal:  Dtsch Arztebl Int       Date:  2012-09-14       Impact factor: 5.594

5.  [Intravitreal treatment of patients with branch retinal vein occlusion depending on the duration of macular edema].

Authors:  M Rehak; E Spies; M Scholz; P Wiedemann
Journal:  Ophthalmologe       Date:  2013-10       Impact factor: 1.059

  5 in total

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