| Literature DB >> 21424598 |
Thais Accorsi-Mendonça1, Willian Fernando Zambuzzi, Clóvis Monteiro Bramante, Tânia Mari Cestari, Rumio Taga, Márcia Sader, Glória Dulce de Almeida Soares, José Mauro Granjeiro.
Abstract
Our purpose was to evaluate the osteoconduction potential of mixed bovine bone (MBB) xenografts as an alternative for bone grafting of critical-size defects in the calvaria of rats. After surgery, in the time intervals of 1, 3, 6, and 9 months, rats were killed and their skulls collected, radiographed and histologically prepared for analysis. The data obtained from histological analysis reported that the particles of MBB did not promote an intense immunological response, evidencing its biocompatibility in rats. Our results clearly showed the interesting evidence that MBB was not completely reabsorbed at 9 months while a small amount of newly formed bone was deposited by osteoprogenitor cells bordering the defect. However, this discrete bone-forming stimulation was unable to regenerate the bone defect. Overall, our results suggest that the properties of MBB are not suitable for stimulating intense bone regeneration in critical bone defects in rats.Entities:
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Year: 2011 PMID： 21424598 DOI： 10.1007/s10856-011-4278-7
Source DB: PubMed Journal: J Mater Sci Mater Med ISSN： 0957-4530 Impact factor: 3.896