| Literature DB >> 21419609 |
S B Erickson1, T J Vrtiska, J C Lieske.
Abstract
Kidney stones are a common problem for which inadequate prevention exists. We recruited ten recurrent kidney stone formers with documented calcium oxalate stones into a two phased study to assess safety and effectiveness of Cystone(®), an herbal treatment for prevention of kidney stones. The first phase was a randomized double-blinded 12 week cross over study assessing the effect of Cystone(®) vs. placebo on urinary supersaturation. The second phase was an open label one year study of Cystone(®) to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. Results revealed no statistically significant effect of Cystone(®) on urinary composition short (6 weeks) or long (52 weeks) term. Average renal stone burden increased rather than decreased on Cystone(®). Therefore, this study does not support the efficacy of Cystone(®) to treat calcium oxalate stone formers. Future studies will be needed to assess effects on stone passage, or on other stone types.Entities:
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Year: 2011 PMID： 21419609 PMCID： PMC3925635 DOI： 10.1016/j.phymed.2011.01.018
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340