Literature DB >> 21412984

Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds.

Kai-Hsuan Chang1, Oliver N F King1, Anthony Tumber2, Esther C Y Woon1, Tom D Heightman2, Michael A McDonough1, Christopher J Schofield1, Nathan R Rose1.   

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Year:  2011        PMID： 21412984      PMCID： PMC4696159          DOI： 10.1002/cmdc.201100026

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  21 in total

Review 1.  Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

Authors:  Paul A C Cloos; Jesper Christensen; Karl Agger; Kristian Helin
Journal:  Genes Dev       Date:  2008-05-01       Impact factor: 11.361

2.  Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

Authors:  Shohei Hamada; Takayoshi Suzuki; Koshiki Mino; Koichi Koseki; Felix Oehme; Ingo Flamme; Hiroki Ozasa; Yukihiro Itoh; Daisuke Ogasawara; Haruka Komaarashi; Aiko Kato; Hiroki Tsumoto; Hidehiko Nakagawa; Makoto Hasegawa; Ryuzo Sasaki; Tamio Mizukami; Naoki Miyata
Journal:  J Med Chem       Date:  2010-08-12       Impact factor: 7.446

3.  3-(2,2,2-Trimethylhydrazinium)propionate (THP)--a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties.

Authors:  B Z Simkhovich; Z V Shutenko; D V Meirena; K B Khagi; R J Mezapuķe; T N Molodchina; I J Kalviņs; E Lukevics
Journal:  Biochem Pharmacol       Date:  1988-01-15       Impact factor: 5.858

4.  Novel inhibitors of prolyl 4-hydroxylase. 5. The intriguing structure-activity relationships seen with 2,2'-bipyridine and its 5,5'-dicarboxylic acid derivatives.

Authors:  N J Hales; J F Beattie
Journal:  J Med Chem       Date:  1993-11-26       Impact factor: 7.446

5.  Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones.

Authors:  T J Franklin; W P Morris; P N Edwards; M S Large; R Stephenson
Journal:  Biochem J       Date:  2001-01-15       Impact factor: 3.857

Review 6.  Therapeutic approaches to organ fibrosis.

Authors:  T J Franklin
Journal:  Int J Biochem Cell Biol       Date:  1997-01       Impact factor: 5.085

7.  Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.

Authors:  Shohei Hamada; Tae-Dong Kim; Takayoshi Suzuki; Yukihiro Itoh; Hiroki Tsumoto; Hidehiko Nakagawa; Ralf Janknecht; Naoki Miyata
Journal:  Bioorg Med Chem Lett       Date:  2009-03-26       Impact factor: 2.823

8.  A miniaturized screen for inhibitors of Jumonji histone demethylases.

Authors:  Masaaki Sakurai; Nathan R Rose; Lena Schultz; Amy M Quinn; Ajit Jadhav; Stanley S Ng; Udo Oppermann; Christopher J Schofield; Anton Simeonov
Journal:  Mol Biosyst       Date:  2009-10-08

9.  Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Authors:  Stanley S Ng; Kathryn L Kavanagh; Michael A McDonough; Danica Butler; Ewa S Pilka; Benoit M R Lienard; James E Bray; Pavel Savitsky; Opher Gileadi; Frank von Delft; Nathan R Rose; John Offer; Johanna C Scheinost; Tomasz Borowski; Michael Sundstrom; Christopher J Schofield; Udo Oppermann
Journal:  Nature       Date:  2007-06-24       Impact factor: 49.962

10.  Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.

Authors:  Jean-François Couture; Evys Collazo; Patricia A Ortiz-Tello; Joseph S Brunzelle; Raymond C Trievel
Journal:  Nat Struct Mol Biol       Date:  2007-06-24       Impact factor: 15.369
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  24 in total

Review 1.  Epigenetic protein families: a new frontier for drug discovery.

Authors:  Cheryl H Arrowsmith; Chas Bountra; Paul V Fish; Kevin Lee; Matthieu Schapira
Journal:  Nat Rev Drug Discov       Date:  2012-04-13       Impact factor: 84.694

2.  Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Authors:  Nathan R Rose; Esther C Y Woon; Anthony Tumber; Louise J Walport; Rasheduzzaman Chowdhury; Xuan Shirley Li; Oliver N F King; Clarisse Lejeune; Stanley S Ng; Tobias Krojer; Mun Chiang Chan; Anna M Rydzik; Richard J Hopkinson; Ka Hing Che; Michelle Daniel; Claire Strain-Damerell; Carina Gileadi; Grazyna Kochan; Ivanhoe K H Leung; James Dunford; Kar Kheng Yeoh; Peter J Ratcliffe; Nicola Burgess-Brown; Frank von Delft; Susanne Muller; Brian Marsden; Paul E Brennan; Michael A McDonough; Udo Oppermann; Robert J Klose; Christopher J Schofield; Akane Kawamura
Journal:  J Med Chem       Date:  2012-07-11       Impact factor: 7.446

Review 3.  Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases.

Authors:  Zhanxin Wang; Dinshaw J Patel
Journal:  Q Rev Biophys       Date:  2013-09-02       Impact factor: 5.318

4.  The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.

Authors:  Barbara Cascella; Soon Goo Lee; Sukrit Singh; Joseph M Jez; Liviu M Mirica
Journal:  Chem Commun (Camb)       Date:  2017-02-09       Impact factor: 6.222

Review 5.  The role of histone demethylases in cancer therapy.

Authors:  Inga Hoffmann; Martin Roatsch; Martin L Schmitt; Luca Carlino; Martin Pippel; Wolfgang Sippl; Manfred Jung
Journal:  Mol Oncol       Date:  2012-08-07       Impact factor: 6.603

6.  Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.

Authors:  Laura A Mike; Ashootosh Tripathi; Connor M Blankenship; Alyssa Saluk; Pamela J Schultz; Giselle Tamayo-Castillo; David H Sherman; Harry L T Mobley
Journal:  Chem Commun (Camb)       Date:  2017-11-28       Impact factor: 6.222

Review 7.  Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.

Authors:  David F Tough; Huw D Lewis; Inmaculada Rioja; Matthew J Lindon; Rab K Prinjha
Journal:  Br J Pharmacol       Date:  2014-11       Impact factor: 8.739

Review 8.  Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.

Authors:  Kelly Marie Arcipowski; Carlos Alberto Martinez; Panagiotis Ntziachristos
Journal:  Curr Opin Genet Dev       Date:  2016-05-03       Impact factor: 5.578

Review 9.  Epigenetics: A primer for clinicians.

Authors:  Benjamin E Paluch; Abdul R Naqash; Zachary Brumberger; Michael J Nemeth; Elizabeth A Griffiths
Journal:  Blood Rev       Date:  2016-02-26       Impact factor: 8.250

Review 10.  Targeting the histone orthography of cancer: drugs for writers, erasers and readers.

Authors:  Laia Simó-Riudalbas; Manel Esteller
Journal:  Br J Pharmacol       Date:  2014-09-05       Impact factor: 8.739
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