Literature DB >> 29139494

Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.

Laura A Mike1, Ashootosh Tripathi, Connor M Blankenship, Alyssa Saluk, Pamela J Schultz, Giselle Tamayo-Castillo, David H Sherman, Harry L T Mobley.   

Abstract

High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 29139494      PMCID： PMC5706644          DOI： 10.1039/c7cc07732g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  36 in total

1.  Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging.

Authors:  Emanuela Messa; Sonia Carturan; Chiara Maffè; Marisa Pautasso; Enrico Bracco; Antonella Roetto; Francesca Messa; Francesca Arruga; Ilaria Defilippi; Valentina Rosso; Chiara Zanone; Antonia Rotolo; Elisabetta Greco; Rosa M Pellegrino; Daniele Alberti; Giuseppe Saglio; Daniela Cilloni
Journal:  Haematologica       Date:  2010-06-09       Impact factor: 9.941

2.  Antibiotic resistance and pyelonephritis.

Authors:  Betsy Foxman; Moran Ki; Patricia Brown
Journal:  Clin Infect Dis       Date:  2007-06-19       Impact factor: 9.079

Review 3.  International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.

Authors:  Kalpana Gupta; Thomas M Hooton; Kurt G Naber; Björn Wullt; Richard Colgan; Loren G Miller; Gregory J Moran; Lindsay E Nicolle; Raul Raz; Anthony J Schaeffer; David E Soper
Journal:  Clin Infect Dis       Date:  2011-03-01       Impact factor: 9.079

4.  Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds.

Authors:  Kai-Hsuan Chang; Oliver N F King; Anthony Tumber; Esther C Y Woon; Tom D Heightman; Michael A McDonough; Christopher J Schofield; Nathan R Rose
Journal:  ChemMedChem       Date:  2011-03-15       Impact factor: 3.466

5.  Redundancy and specificity of Escherichia coli iron acquisition systems during urinary tract infection.

Authors:  Erin C Garcia; Ariel R Brumbaugh; Harry L T Mobley
Journal:  Infect Immun       Date:  2011-01-10       Impact factor: 3.441

6.  Universal chemical assay for the detection and determination of siderophores.

Authors:  B Schwyn; J B Neilands
Journal:  Anal Biochem       Date:  1987-01       Impact factor: 3.365

7.  Identification of uropathogenic Escherichia coli surface proteins by shotgun proteomics.

Authors:  Matthew S Walters; Harry L T Mobley
Journal:  J Microbiol Methods       Date:  2009-05-06       Impact factor: 2.363

8.  Escherichia coli global gene expression in urine from women with urinary tract infection.

Authors:  Erin C Hagan; Amanda L Lloyd; David A Rasko; Gary J Faerber; Harry L T Mobley
Journal:  PLoS Pathog       Date:  2010-11-11       Impact factor: 6.823

9.  Mucosal immunization with iron receptor antigens protects against urinary tract infection.

Authors:  Christopher J Alteri; Erin C Hagan; Kelsey E Sivick; Sara N Smith; Harry L T Mobley
Journal:  PLoS Pathog       Date:  2009-09-18       Impact factor: 6.823

10.  Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway.

Authors:  Sung Ryeol Park; Ashootosh Tripathi; Jianfeng Wu; Pamela J Schultz; Isaiah Yim; Thomas J McQuade; Fengan Yu; Carl-Johan Arevang; Abraham Y Mensah; Giselle Tamayo-Castillo; Chuanwu Xi; David H Sherman
Journal:  Nat Commun       Date:  2016-02-16       Impact factor: 14.919
View more
  2 in total

1.  Adipostatins E-J, New Potent Antimicrobials Identified as Inhibitors of Coenzyme-A Biosynthesis.

Authors:  Lyanne Gómez-Rodríguez; Pamela J Schultz; Giselle Tamayo-Castillo; Garry D Dotson; David H Sherman; Ashootosh Tripathi
Journal:  Tetrahedron Lett       Date:  2019-12-02       Impact factor: 2.415

2.  Metabolomic Profiling and Molecular Networking of Nudibranch-Associated Streptomyces sp. SCSIO 001680.

Authors:  Samar M Abdelrahman; Noura S Dosoky; Amro M Hanora; Nicole B Lopanik
Journal:  Molecules       Date:  2022-07-16       Impact factor: 4.927
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.