Literature DB >> 21411222

p16(INK4a)/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough?

Mario Pérez-Sayáns1, José Manuel Suárez-Peñaranda, Pilar Gayoso-Diz, Francisco Barros-Angueira, José Manuel Gándara-Rey, Abel García-García.   

Abstract

Oral squamous cell carcinomas (OSCC) are the most common malignancy of the oral cavity and their multistep development requires the accumulation of multiple genetic and epigenetic alterations. Inactivation of p16(INK4a), encoded by the CDKN2 gene has been widely associated with this type of tumors. The purpose of this review is to elucidate the relationship between p16(INK4a) expression and the different clinical and pathological aspects of OSCC, analyze the variation in results between studies, detailing the described genetic/epigenetic alterations that result in gene silencing and the relationship between p16(INK4a) and HPV infection.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 21411222     DOI： 10.1016/j.canlet.2011.02.039

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  Rnf2 knockdown reduces cell viability and promotes cell cycle arrest in gastric cancer cells.

Authors:  Jingfang Zhang; Zhenni Sun; Yafei Han; Ruyong Yao; Lu Yue; Yan Xu; Jisheng Zhang
Journal:  Oncol Lett       Date:  2017-03-17       Impact factor: 2.967

2.  Immunohistochemical expression of p16 in Carcinoma Ex-pleomorphic Adenoma (undifferentiated and Adenocarcinoma Types).

Authors:  Bassel Tarakji; Mohammed Alsakran Altamimi; Kusai Baroudi; Mohammad Z Nassain; Faris Q Alenzi
Journal:  J Clin Diagn Res       Date:  2013-12-15

3.  Immunohistochemical Detection of p16(INK4a) in Leukoplakia and Oral Squamous Cell Carcinoma.

Authors:  Pradyot Prakash; Muktesh Khandare; Mohan Kumar; Rahul Khanna; Gyan Prakash Singh; Gopal Nath; Anil Kumar Gulati
Journal:  J Clin Diagn Res       Date:  2013-12-15

Review 4.  Lessons learned from next-generation sequencing in head and neck cancer.

Authors:  Myriam Loyo; Ryan J Li; Chetan Bettegowda; Curtis R Pickering; Mitchell J Frederick; Jeffrey N Myers; Nishant Agrawal
Journal:  Head Neck       Date:  2012-08-21       Impact factor: 3.147

Review 5.  The molecular pathogenesis of head and neck squamous cell carcinoma.

Authors:  S Michael Rothenberg; Leif W Ellisen
Journal:  J Clin Invest       Date:  2012-06       Impact factor: 14.808

6.  Unraveling the molecular genetics of head and neck cancer through genome-wide approaches.

Authors:  Nadeem Riaz; Luc G Morris; William Lee; Timothy A Chan
Journal:  Genes Dis       Date:  2014-09

7.  p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck.

Authors:  Miguel Reis DE Almeida; Mario Pérez-Sayáns; José Manuel Suárez-Peñaranda; José Manuel Somoza-Martín; Abel García-García
Journal:  Oncol Lett       Date:  2015-09-18       Impact factor: 2.967

Review 8.  p16INK4A and p14ARF gene promoter hypermethylation as prognostic biomarker in oral and oropharyngeal squamous cell carcinoma: a review.

Authors:  A Al-Kaabi; L W van Bockel; A J Pothen; S M Willems
Journal:  Dis Markers       Date:  2014-04-07       Impact factor: 3.434

Review 9.  Advances in the management of squamous cell carcinoma of the head and neck.

Authors:  Jean-Pascal Machiels; Maarten Lambrecht; François-Xavier Hanin; Thierry Duprez; Vincent Gregoire; Sandra Schmitz; Marc Hamoir
Journal:  F1000Prime Rep       Date:  2014-06-02

10.  Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma.

Authors:  Vikram Bhatia; Madhu Mati Goel; Annu Makker; Shikha Tewari; Alka Yadu; Priyanka Shilpi; Sandeep Kumar; S P Agarwal; Sudhir K Goel
Journal:  Biomed Res Int       Date:  2014-06-02       Impact factor: 3.411
  10 in total

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