Bassel Tarakji1, Mohammed Alsakran Altamimi2, Kusai Baroudi2, Mohammad Z Nassain2, Faris Q Alenzi3. 1. Faculty, Head of Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry and Nursing , Kingdom of Saudi Arabia, Riyadh . 2. Faculty, Department of Restorative Dental Sciences, Alfarabi College of Dentistry and Nursing , Kingdom of Saudi Arabia, Riyadh . 3. Faculty, College of Applied Medical Sciences, Prince Salman University , Al-Kharj, Saudi Arabia .
Abstract
OBJECTIVE: This study was aimed at characterizing alterations in the immunohistochemical expression of p16 in carcinoma ex-pleomorphic adenomas. STUDY DESIGN: A selected series of 27 cases of carcinoma ex-pleomorphic adenomas were examined. RESULTS: The results showed that p16 expression in non tumour duct cells was strongly positive nuclear staining in 23 (85%) cases out of 27 cases, that 3 (11.1%) had moderate staining, and that 1 (3.7%) had weak staining. p16 expression in carcinoma ex-pleomorphic adenomas was indicated as a negative nuclear staining in 22 (81.4%) cases out of 27cases, and 5 (18.5%) cases expressed moderate staining. CONCLUSION: This study suggests that alteration of p16 expression is detected in carcinoma ex-pleomorphic adenomas. p16 has a role in development of carcinoma ex-pleomorphic adenomas.
OBJECTIVE: This study was aimed at characterizing alterations in the immunohistochemical expression of p16 in carcinoma ex-pleomorphic adenomas. STUDY DESIGN: A selected series of 27 cases of carcinoma ex-pleomorphic adenomas were examined. RESULTS: The results showed that p16 expression in non tumour duct cells was strongly positive nuclear staining in 23 (85%) cases out of 27 cases, that 3 (11.1%) had moderate staining, and that 1 (3.7%) had weak staining. p16 expression in carcinoma ex-pleomorphic adenomas was indicated as a negative nuclear staining in 22 (81.4%) cases out of 27cases, and 5 (18.5%) cases expressed moderate staining. CONCLUSION: This study suggests that alteration of p16 expression is detected in carcinoma ex-pleomorphic adenomas. p16 has a role in development of carcinoma ex-pleomorphic adenomas.
Authors: Mario Pérez-Sayáns; José Manuel Suárez-Peñaranda; Pilar Gayoso-Diz; Francisco Barros-Angueira; José Manuel Gándara-Rey; Abel García-García Journal: Cancer Lett Date: 2011-03-15 Impact factor: 8.679
Authors: N Chooback; Y Shen; M Jones; K Kasaian; M Martin; T Ng; T Thomson; M Marra; J Laskin; C Ho Journal: Curr Oncol Date: 2017-06-27 Impact factor: 3.677