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Literature DB >> 21406552

RNAi genes pave their own way.

Abstract

Heterochromatin formation in fission yeast and the role of RNAi in this process have been intensively studied. So far, however, nothing is known about the regulation of expression of RNAi components during these events. Gullerova and colleagues (pp. 556-568) reveal an autoregulatory loop that regulates the expression of RNAi genes and centromeric heterochromatin formation during the cell cycle. Gene orientation plays a surprising role in this process.

Entities: Chemical

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Year: 2011 PMID： 21406552 PMCID： PMC3059828 DOI： 10.1101/gad.2038611

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

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References

32 in total

1. Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin.

Authors: Songtao Jia; Ryuji Kobayashi; Shiv I S Grewal
Journal: Nat Cell Biol Date: 2005-08-28 Impact factor: 28.824

2. A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.

Authors: Eun-Jin Erica Hong; Judit Villén; Erica L Gerace; Steven P Gygi; Danesh Moazed
Journal: RNA Biol Date: 2005-07-30 Impact factor: 4.652

RNAi genes pave their own way.

1. Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin.

2. A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.

3. Opening closed arms: long-distance activation of SMC ATPase by hinge-DNA interactions.

4. Cohesin complex promotes transcriptional termination between convergent genes in S. pombe.

5. RNA interference guides histone modification during the S phase of chromosomal replication.

6. Autoregulation of convergent RNAi genes in fission yeast.

Review 7. RNA interference and heterochromatin in the fission yeast Schizosaccharomyces pombe.

8. Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe.

9. Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome.

Review 10. Cell-cycle control of gene expression in budding and fission yeast.