Literature DB >> 21394327

Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling.

Samuel Reyes1, Robert W Huigens, Zhaoming Su, Michel L Simon, Christian Melander.   

Abstract

A pilot library of 2-aminoimidazole triazoles (2-AITs) was synthesized and assayed against Acinetobacter baumannii and methicillin-resistant Staphylococus aureus (MRSA). Results from these studies show that these new derivatives have improved biofilm dispersal activities as well as antibacterial properties against A. baumannii. With MRSA biofilms they are found to possess biofilm inhibition capabilities at low micromolar concentrations.

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Year:  2011        PMID： 21394327     DOI： 10.1039/c0ob00925c

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  8 in total

Review 1.  Small molecule control of bacterial biofilms.

Authors:  Roberta J Worthington; Justin J Richards; Christian Melander
Journal:  Org Biomol Chem       Date:  2012-10-07       Impact factor: 3.876

2.  2-Aminopyrimidine as a novel scaffold for biofilm modulation.

Authors:  Erick A Lindsey; Roberta J Worthington; Cristina Alcaraz; Christian Melander
Journal:  Org Biomol Chem       Date:  2012-02-02       Impact factor: 3.876

3.  A new small molecule inhibits Streptococcus mutans biofilms in vitro and in vivo.

Authors:  W Pan; M Fan; H Wu; C Melander; C Liu
Journal:  J Appl Microbiol       Date:  2015-09-24       Impact factor: 3.772

4.  The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.

Authors:  Erick A Lindsey; Christopher M Brackett; Trey Mullikin; Cristina Alcaraz; Christian Melander
Journal:  Medchemcomm       Date:  2012-09-18       Impact factor: 3.597

5.  Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa.

Authors:  Gabriel Navarro; Andrew T Cheng; Kelly C Peach; Walter M Bray; Valerie S Bernan; Fitnat H Yildiz; Roger G Linington
Journal:  Antimicrob Agents Chemother       Date:  2013-12-02       Impact factor: 5.191

6.  Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus.

Authors:  Matthew D Stephens; Nisakorn Yodsanit; Christian Melander
Journal:  Org Biomol Chem       Date:  2016-07-12       Impact factor: 3.876

7.  Interaction of pyrrolobenzodiazepine (PBD) ligands with parallel intermolecular G-quadruplex complex using spectroscopy and ESI-MS.

Authors:  Gajjela Raju; Ragampeta Srinivas; Vangala Santhosh Reddy; Mohammed M Idris; Ahmed Kamal; Narayana Nagesh
Journal:  PLoS One       Date:  2012-04-27       Impact factor: 3.240

8.  Chemoenzymatic Hunsdiecker-Type Decarboxylative Bromination of Cinnamic Acids.

Authors:  Huanhuan Li; Sabry H H Younes; Shaohang Chen; Peigao Duan; Chengsen Cui; Ron Wever; Wuyuan Zhang; Frank Hollmann
Journal:  ACS Catal       Date:  2022-04-04       Impact factor: 13.700
  8 in total

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