Literature DB >> 21394102

The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?

A Vilborg1, C Bersani, M T Wilhelm, K G Wiman.   

Abstract

Wig-1 is a transcriptional target of the tumor suppressor p53 and encodes an unusual zinc-finger protein involved in post-transcriptional gene regulation. Wig-1 is expressed in all cell types investigated so far, with the highest levels in the brain, and is enriched in stem cells as compared with more differentiated cells of the same lineage. Wig-1 binds to both long double-stranded (ds) RNA and short microRNA-like dsRNA. We have shown that Wig-1 acts in a positive feedback loop that stabilizes p53 mRNA through an AU-rich element (ARE) in the p53 3'untranslated region. Our preliminary data indicate a more general effect of Wig-1 on ARE-containing mRNA. Here we shall summarize current knowledge about Wig-1 and discuss possible implications on p53 function and other cellular processes.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21394102      PMCID： PMC3178426          DOI： 10.1038/cdd.2011.20

Source DB:  PubMed          Journal:  Cell Death Differ        ISSN： 1350-9047            Impact factor:   15.828


  67 in total

1.  Transcript profiling during preimplantation mouse development.

Authors:  Fanyi Zeng; Don A Baldwin; Richard M Schultz
Journal:  Dev Biol       Date:  2004-08-15       Impact factor: 3.582

Review 2.  Post-transcriptional regulation in cancer.

Authors:  Yann Audic; Rebecca S Hartley
Journal:  Biol Cell       Date:  2004-09       Impact factor: 4.458

3.  Efficient isolation and gene expression profiling of small numbers of neural crest stem cells and developing Schwann cells.

Authors:  Johanna Buchstaller; Lukas Sommer; Matthias Bodmer; Reinhard Hoffmann; Ueli Suter; Ned Mantei
Journal:  J Neurosci       Date:  2004-03-10       Impact factor: 6.167

4.  Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein.

Authors:  G Reuter; M Giarre; J Farah; J Gausz; A Spierer; P Spierer
Journal:  Nature       Date:  1990-03-15       Impact factor: 49.962

5.  Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells.

Authors:  Stefanie Galbán; Jennifer L Martindale; Krystyna Mazan-Mamczarz; Isabel López de Silanes; Jinshui Fan; Wengong Wang; Jochen Decker; Myriam Gorospe
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

6.  Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.

Authors:  Ting Chen; Amy M Brownawell; Ian G Macara
Journal:  Mol Cell Biol       Date:  2004-08       Impact factor: 4.272

7.  Genetic diagnosis by comparative genomic hybridization in adult de novo acute myelocytic leukemia.

Authors:  Sílvia Casas; Anna Aventín; Francisca Fuentes; Teresa Vallespí; Isabel Granada; Anna Carrió; José Angel Martínez-Climent; Francesc Solé; Montserrat Teixidó; Marta Bernués; José Duarte; Jesús Maria Hernández; Salut Brunet; Maria Dolors Coll; Jorge Sierra
Journal:  Cancer Genet Cytogenet       Date:  2004-08

8.  The p53-induced Wig-1 zinc finger protein is highly conserved from fish to man.

Authors:  Fredrik Hellborg; Klas G Wiman
Journal:  Int J Oncol       Date:  2004-06       Impact factor: 5.650

9.  RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.

Authors:  Krystyna Mazan-Mamczarz; Stefanie Galbán; Isabel López de Silanes; Jennifer L Martindale; Ulus Atasoy; Jack D Keene; Myriam Gorospe
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-23       Impact factor: 12.779

10.  Molecular signatures of proliferation and quiescence in hematopoietic stem cells.

Authors:  Teresa A Venezia; Akil A Merchant; Carlos A Ramos; Nathan L Whitehouse; Andrew S Young; Chad A Shaw; Margaret A Goodell
Journal:  PLoS Biol       Date:  2004-09-28       Impact factor: 8.029
View more
  16 in total

1.  The paths to death and differentiation.

Authors:  A J Levine
Journal:  Cell Death Differ       Date:  2011-09       Impact factor: 15.828

2.  Zinc induces cell cycle arrest and apoptosis by upregulation of WIG-1 in esophageal squamous cancer cell line EC109.

Authors:  Wei Guo; Ying-Bo Zou; Yao-Guang Jiang; Ru-Wen Wang; Yun-Ping Zhao; Zheng Ma
Journal:  Tumour Biol       Date:  2011-05-11

3.  An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers.

Authors:  Yujia Wen; Eric R Gamazon; Wasim K Bleibel; Claudia Wing; Shuangli Mi; Bridget E McIlwee; Shannon M Delaney; Shiwei Duan; Hae Kyung Im; M Eileen Dolan
Journal:  Hum Mol Genet       Date:  2011-12-13       Impact factor: 6.150

4.  Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype.

Authors:  Mahesh Ramamoorthy; Peter Sykora; Morten Scheibye-Knudsen; Christopher Dunn; Cindy Kasmer; Yongqing Zhang; Kevin G Becker; Deborah L Croteau; Vilhelm A Bohr
Journal:  Free Radic Biol Med       Date:  2012-08-03       Impact factor: 7.376

5.  Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth.

Authors:  A Vilborg; C Bersani; M Wickström; L Segerström; P Kogner; K G Wiman
Journal:  Cell Death Dis       Date:  2012-04-19       Impact factor: 8.469

Review 6.  p63 the guardian of human reproduction.

Authors:  Ivano Amelio; Francesca Grespi; Margherita Annicchiarico-Petruzzelli; Gerry Melino
Journal:  Cell Cycle       Date:  2012-11-19       Impact factor: 4.534

7.  MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix.

Authors:  Mara Mancini; Gaelle Saintigny; Christian Mahé; Margherita Annicchiarico-Petruzzelli; Gerry Melino; Eleonora Candi
Journal:  Aging (Albany NY)       Date:  2012-11       Impact factor: 5.682

8.  Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma.

Authors:  Li-Di Xu; Susanne Muller; Srinivasan R Thoppe; Fredrik Hellborg; Lena Kanter; Mikael Lerner; Biying Zheng; Svetlana Bajalica Lagercrantz; Dan Grandér; Keng Ling Wallin; Klas G Wiman; Catharina Larsson; Sonia Andersson
Journal:  PLoS One       Date:  2014-11-07       Impact factor: 3.240

9.  Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta.

Authors:  Shalom Madar; Einav Harel; Ido Goldstein; Yan Stein; Ira Kogan-Sakin; Iris Kamer; Hilla Solomon; Elya Dekel; Perry Tal; Naomi Goldfinger; Gilgi Friedlander; Varda Rotter
Journal:  PLoS One       Date:  2013-04-22       Impact factor: 3.240

10.  Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ.

Authors:  C Bersani; L-D Xu; A Vilborg; W-O Lui; K G Wiman
Journal:  Oncogene       Date:  2014-01-27       Impact factor: 9.867
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.