Literature DB >> 2107402

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein.

G Reuter1, M Giarre, J Farah, J Gausz, A Spierer, P Spierer.   

Abstract

Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.

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Year:  1990        PMID： 2107402     DOI： 10.1038/344219a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  97 in total

1.  The AT-hook protein D1 is essential for Drosophila melanogaster development and is implicated in position-effect variegation.

Authors:  Nathalie Aulner; Caroline Monod; Guillaume Mandicourt; Denis Jullien; Olivier Cuvier; Alhousseynou Sall; Sam Janssen; Ulrich K Laemmli; Emmanuel Käs
Journal:  Mol Cell Biol       Date:  2002-02       Impact factor: 4.272

2.  Position-effect variegation in Drosophila: the modifier Su(var)3-7 is a modular DNA-binding protein.

Authors:  F Cléard; P Spierer
Journal:  EMBO Rep       Date:  2001-11-21       Impact factor: 8.807

3.  Recombinogenic effects of suppressors of position-effect variegation in Drosophila.

Authors:  Thomas Westphal; Gunter Reuter
Journal:  Genetics       Date:  2002-02       Impact factor: 4.562

4.  JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila.

Authors:  Huai Deng; Weili Cai; Chao Wang; Stephanie Lerach; Marion Delattre; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  Genetics       Date:  2010-05-10       Impact factor: 4.562

5.  A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila.

Authors:  Chao Wang; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  Genetics       Date:  2011-04-21       Impact factor: 4.562

6.  Isolation of Su(var)3-7 mutations by homologous recombination in Drosophila melanogaster.

Authors:  Carole Seum; Daniel Pauli; Marion Delattre; Yannis Jaquet; Anne Spierer; Pierre Spierer
Journal:  Genetics       Date:  2002-07       Impact factor: 4.562

7.  Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila.

Authors:  Ho-Ryun Chung; Ulrich Schäfer; Herbert Jäckle; Siegfried Böhm
Journal:  EMBO Rep       Date:  2002-11-21       Impact factor: 8.807

8.  Antibodies to defined histone epitopes reveal variations in chromatin conformation and underacetylation of centric heterochromatin in human metaphase chromosomes.

Authors:  P Jeppesen; A Mitchell; B Turner; P Perry
Journal:  Chromosoma       Date:  1992-03       Impact factor: 4.316

9.  Basonuclin: a keratinocyte protein with multiple paired zinc fingers.

Authors:  H Tseng; H Green
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

10.  The polar-lethal Ovum mutant gene maps to the distal portion of mouse chromosome 11.

Authors:  C Sapienza; J Paquette; P Pannunzio; S Albrechtson; K Morgan
Journal:  Genetics       Date:  1992-09       Impact factor: 4.562
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