Literature DB >> 21391906

Pharmacologic activation of p53 by small-molecule MDM2 antagonists.

Hong Shen1, Carl G Maki.   

Abstract

Restoring p53 activity by inhibiting the interaction between p53 and MDM2 represents an attractive approach for cancer therapy. To this end, a number of small-molecule p53-MDM2 binding inhibitors have been developed during the past several years. Nutlin-3 is a potent and selective small-molecule MDM2 antagonist that has shown considerable promise in pre-clinical studies. This review will highlight recent advances in the development of small-molecule MDM2 antagonists as potential cancer therapeutics, with special emphasis on Nutlin-3.

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Year:  2011        PMID： 21391906      PMCID： PMC3613239          DOI： 10.2174/138161211795222603

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  104 in total

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Journal:  Nature       Date:  2000-11-16       Impact factor: 49.962

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Journal:  EMBO Rep       Date:  2001-10-17       Impact factor: 8.807

3.  The MDM2 RING-finger domain is required to promote p53 nuclear export.

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Journal:  Nat Cell Biol       Date:  2000-09       Impact factor: 28.824

4.  An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

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Journal:  Nat Cell Biol       Date:  2000-09       Impact factor: 28.824

5.  Multiple roles of mouse Numb in tuning developmental cell fates.

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Journal:  Curr Biol       Date:  2001-04-03       Impact factor: 10.834

6.  p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells.

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Journal:  Oncogene       Date:  2000-04-20       Impact factor: 9.867

7.  Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.

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Journal:  Mol Cell Biol       Date:  2004-09       Impact factor: 4.272

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Authors:  Lyubomir T Vassilev; Binh T Vu; Bradford Graves; Daisy Carvajal; Frank Podlaski; Zoran Filipovic; Norman Kong; Ursula Kammlott; Christine Lukacs; Christian Klein; Nader Fotouhi; Emily A Liu
Journal:  Science       Date:  2004-01-02       Impact factor: 47.728

Review 9.  MDM2, an introduction.

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Journal:  Mol Cancer Res       Date:  2003-12       Impact factor: 5.852

10.  Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5.

Authors:  Mu-Shui Dai; Hua Lu
Journal:  J Biol Chem       Date:  2004-08-11       Impact factor: 5.157
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3.  Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma.

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Review 6.  The effects of chromium(VI) on the thioredoxin system: implications for redox regulation.

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7.  Transient expansion of TP53 mutated clones in polycythemia vera patients treated with idasanutlin.

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Review 10.  Impact of EBV essential nuclear protein EBNA-3C on B-cell proliferation and apoptosis.

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