Yanbei Kuang1,2,3,4, Jian Kang5, Hongbin Li6, Bingtao Liu1,2,3,4, Xueshan Zhao7, Linying Li1,2,3,4, Xiaodong Jin8,9,10,11, Qiang Li12,13,14,15. 1. Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China. 2. Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, 730000, China. 3. Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou, 730000, Gansu, China. 4. University of Chinese Academy of Sciences, Beijing, 100049, China. 5. College of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou, 730050, China. 6. School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China. 7. The First Hospital of Lanzhou University, Lanzhou, 730000, China. 8. Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China. jinxd@impcas.ac.cn. 9. Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, 730000, China. jinxd@impcas.ac.cn. 10. Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou, 730000, Gansu, China. jinxd@impcas.ac.cn. 11. University of Chinese Academy of Sciences, Beijing, 100049, China. jinxd@impcas.ac.cn. 12. Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China. liqiang@impcas.ac.cn. 13. Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, 730000, China. liqiang@impcas.ac.cn. 14. Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou, 730000, Gansu, China. liqiang@impcas.ac.cn. 15. University of Chinese Academy of Sciences, Beijing, 100049, China. liqiang@impcas.ac.cn.
Abstract
BACKGROUND: Greater than half of cancer patients experience radiation therapy, for both radical and palliative objectives. It is well known that researches on radiation response mechanisms are conducive to improve the efficacy of cancer radiotherapy. p21 was initially identified as a widespread inhibitor of cyclin-dependent kinases, transcriptionally modulated by p53 and a marker of cellular senescence. It was once considered that p21 acts as a tumour suppressor mainly to restrain cell cycle progression, thereby resulting in growth suppression. With the deepening researches on p21, p21 has been found to regulate radiation responses via participating in multiple cellular processes, including cell cycle arrest, apoptosis, DNA repair, senescence and autophagy. Hence, a comprehensive summary of the p21's functions in radiation response will provide a new perspective for radiotherapy against cancer. METHODS: We summarize the recent pertinent literature from various electronic databases, including PubMed and analyzed several datasets from Gene Expression Omnibus database. This review discusses how p21 influences the effect of cancer radiotherapy via involving in multiple signaling pathways and expounds the feasibility, barrier and risks of using p21 as a biomarker as well as a therapeutic target of radiotherapy. CONCLUSION: p21's complicated and important functions in cancer radiotherapy make it a promising therapeutic target. Besides, more thorough insights of p21 are needed to make it a safe therapeutic target.
BACKGROUND: Greater than half of cancerpatients experience radiation therapy, for both radical and palliative objectives. It is well known that researches on radiation response mechanisms are conducive to improve the efficacy of cancer radiotherapy. p21 was initially identified as a widespread inhibitor of cyclin-dependent kinases, transcriptionally modulated by p53 and a marker of cellular senescence. It was once considered that p21 acts as a tumour suppressor mainly to restrain cell cycle progression, thereby resulting in growth suppression. With the deepening researches on p21, p21 has been found to regulate radiation responses via participating in multiple cellular processes, including cell cycle arrest, apoptosis, DNA repair, senescence and autophagy. Hence, a comprehensive summary of the p21's functions in radiation response will provide a new perspective for radiotherapy against cancer. METHODS: We summarize the recent pertinent literature from various electronic databases, including PubMed and analyzed several datasets from Gene Expression Omnibus database. This review discusses how p21 influences the effect of cancer radiotherapy via involving in multiple signaling pathways and expounds the feasibility, barrier and risks of using p21 as a biomarker as well as a therapeutic target of radiotherapy. CONCLUSION:p21's complicated and important functions in cancer radiotherapy make it a promising therapeutic target. Besides, more thorough insights of p21 are needed to make it a safe therapeutic target.
Entities:
Keywords:
Apoptosis; Cancer radiotherapy; Cell cycle; DNA damage repair; p21
Authors: C Badie; S Dziwura; C Raffy; T Tsigani; G Alsbeih; J Moody; P Finnon; E Levine; D Scott; S Bouffler Journal: Br J Cancer Date: 2008-05-20 Impact factor: 7.640
Authors: Elena G Novoselova; Mars G Sharapov; Sergey M Lunin; Svetlana B Parfenyuk; Maxim O Khrenov; Elvira K Mubarakshina; Anna A Kuzekova; Tatyana V Novoselova; Ruslan G Goncharov; Olga V Glushkova Journal: Antioxidants (Basel) Date: 2021-12-05