Literature DB >> 21388881

Intraflagellar transport: a new player at the immune synapse.

Francesca Finetti1, Silvia Rossi Paccani, Joel Rosenbaum, Cosima T Baldari.   

Abstract

The assembly and maintenance of primary cilia, which orchestrate signaling pathways centrally implicated in cell proliferation, differentiation and migration, are ensured by multimeric protein particles in a process known as intraflagellar transport (IFT). It has recently been demonstrated that a number of IFT components are expressed in hematopoietic cells, which have no cilia. Here, we summarize data for an unexpected role of IFT proteins in immune synapse assembly and intracellular membrane trafficking in T lymphocytes, and discuss the hypothesis that the immune synapse could represent the functional homolog of the primary cilium in these cells.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21388881      PMCID： PMC4060984          DOI： 10.1016/j.it.2011.02.001

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  59 in total

1.  The immunological synapse: a molecular machine controlling T cell activation.

Authors:  A Grakoui; S K Bromley; C Sumen; M M Davis; A S Shaw; P M Allen; M L Dustin
Journal:  Science       Date:  1999-07-09       Impact factor: 47.728

Review 2.  Common themes in centriole and centrosome movements.

Authors:  Sue Vaughan; Helen R Dawe
Journal:  Trends Cell Biol       Date:  2010-10-18       Impact factor: 20.808

Review 3.  Nodal flow and the generation of left-right asymmetry.

Authors:  Nobutaka Hirokawa; Yosuke Tanaka; Yasushi Okada; Sen Takeda
Journal:  Cell       Date:  2006-04-07       Impact factor: 41.582

Review 4.  Immune synapses in T-cell activation.

Authors:  Saso Cemerski; Andrey Shaw
Journal:  Curr Opin Immunol       Date:  2006-04-17       Impact factor: 7.486

5.  Three-dimensional segregation of supramolecular activation clusters in T cells.

Authors:  C R Monks; B A Freiberg; H Kupfer; N Sciaky; A Kupfer
Journal:  Nature       Date:  1998-09-03       Impact factor: 49.962

6.  A motility in the eukaryotic flagellum unrelated to flagellar beating.

Authors:  K G Kozminski; K A Johnson; P Forscher; J L Rosenbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

7.  Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation.

Authors:  U D'Oro; M S Vacchio; A M Weissman; J D Ashwell
Journal:  Immunity       Date:  1997-11       Impact factor: 31.745

8.  Molecular characterization of the di-leucine-based internalization motif of the T cell receptor.

Authors:  J Dietrich; X Hou; A M Wegener; L O Pedersen; N Odum; C Geisler
Journal:  J Biol Chem       Date:  1996-05-10       Impact factor: 5.157

9.  Two distinct pathways exist for down-regulation of the TCR.

Authors:  J P Lauritsen; M D Christensen; J Dietrich; J Kastrup; N Odum; C Geisler
Journal:  J Immunol       Date:  1998-07-01       Impact factor: 5.422

Review 10.  The c-SMAC: sorting it all out (or in).

Authors:  Joseph Lin; Mark J Miller; Andrey S Shaw
Journal:  J Cell Biol       Date:  2005-07-11       Impact factor: 10.539
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  26 in total

Review 1.  The complexity of the cilium: spatiotemporal diversity of an ancient organelle.

Authors:  Westley Heydeck; Lorraine Fievet; Erica E Davis; Nicholas Katsanis
Journal:  Curr Opin Cell Biol       Date:  2018-08-20       Impact factor: 8.382

Review 2.  Primary cilia proteins: ciliary and extraciliary sites and functions.

Authors:  Kiet Hua; Russell J Ferland
Journal:  Cell Mol Life Sci       Date:  2018-01-05       Impact factor: 9.261

Review 3.  Transfer of extracellular vesicles during immune cell-cell interactions.

Authors:  Cristina Gutiérrez-Vázquez; Carolina Villarroya-Beltri; María Mittelbrunn; Francisco Sánchez-Madrid
Journal:  Immunol Rev       Date:  2013-01       Impact factor: 12.988

Review 4.  Ciliary signalling in cancer.

Authors:  Hanqing Liu; Anna A Kiseleva; Erica A Golemis
Journal:  Nat Rev Cancer       Date:  2018-08       Impact factor: 60.716

5.  Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.

Authors:  Michelle S Levine; Bjorn Bakker; Bram Boeckx; Julia Moyett; James Lu; Benjamin Vitre; Diana C Spierings; Peter M Lansdorp; Don W Cleveland; Diether Lambrechts; Floris Foijer; Andrew J Holland
Journal:  Dev Cell       Date:  2017-01-26       Impact factor: 12.270

Review 6.  Functional Diversity of Ciliary Proteins in Bone Development and Disease.

Authors:  Masaru Kaku; Yoshihiro Komatsu
Journal:  Curr Osteoporos Rep       Date:  2017-04       Impact factor: 5.096

Review 7.  Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton.

Authors:  Xue Yuan; Rosa A Serra; Shuying Yang
Journal:  Ann N Y Acad Sci       Date:  2014-06-24       Impact factor: 5.691

8.  Primary cilia are present on human blood and bone marrow cells and mediate Hedgehog signaling.

Authors:  Mohan Singh; Parvesh Chaudhry; Akil A Merchant
Journal:  Exp Hematol       Date:  2016-09-07       Impact factor: 3.084

9.  LZTFL1 Upregulated by All-Trans Retinoic Acid during CD4+ T Cell Activation Enhances IL-5 Production.

Authors:  Hong Jiang; Kanyarat Promchan; Bor-Ruei Lin; Stephen Lockett; De Chen; Heather Marshall; Yunden Badralmaa; Ven Natarajan
Journal:  J Immunol       Date:  2015-12-23       Impact factor: 5.422

10.  The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.

Authors:  Stefanie L Butland; Shaun S Sanders; Mandi E Schmidt; Sean-Patrick Riechers; David T S Lin; Dale D O Martin; Kuljeet Vaid; Rona K Graham; Roshni R Singaraja; Erich E Wanker; Elizabeth Conibear; Michael R Hayden
Journal:  Hum Mol Genet       Date:  2014-04-04       Impact factor: 6.150
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