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Literature DB >> 29802351

Ciliary signalling in cancer.

Hanqing Liu¹, Anna A Kiseleva^2,3, Erica A Golemis⁴.

Abstract

Although tumours initiate from oncogenic changes in a cancer cell, subsequent tumour progression and therapeutic response depend on interactions between the cancer cells and the tumour microenvironment (TME). The primary monocilium, or cilium, provides a spatially localized platform for signalling by Hedgehog, Notch, WNT and some receptor tyrosine kinase pathways and mechanosensation. Changes in ciliation of cancer cells and/or cells of the TME during tumour development enforce asymmetric intercellular signalling in the TME. Growing evidence indicates that some oncogenic signalling pathways as well as some targeted anticancer therapies induce ciliation, while others repress it. The links between the genomic profile of cancer cells, drug treatment and ciliary signalling in the TME likely affect tumour growth and therapeutic response.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2018 PMID： 29802351 PMCID： PMC6448793 DOI： 10.1038/s41568-018-0023-6

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

181 in total

1. Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways.

Authors: Shixuan Wang; Man J Livingston; Yunchao Su; Zheng Dong
Journal: Autophagy Date: 2015-04-03 Impact factor: 16.016

2. Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).

Authors: Anna S Nikonova; Alexander Y Deneka; Anna A Kiseleva; Vladislav Korobeynikov; Anna Gaponova; Ilya G Serebriiskii; Meghan C Kopp; Harvey H Hensley; Tamina N Seeger-Nukpezah; Stefan Somlo; David A Proia; Erica A Golemis
Journal: FASEB J Date: 2018-01-10 Impact factor: 5.191

3. A chemical screen identifies class a g-protein coupled receptors as regulators of cilia.

Authors: Prachee Avasthi; Aaron Marley; Henry Lin; Elisabet Gregori-Puigjane; Brian K Shoichet; Mark von Zastrow; Wallace F Marshall
Journal: ACS Chem Biol Date: 2012-03-08 Impact factor: 5.100

4. Primary cilia regulate branching morphogenesis during mammary gland development.

Authors: Kimberly M McDermott; Bob Y Liu; Thea D Tlsty; Gregory J Pazour
Journal: Curr Biol Date: 2010-04-08 Impact factor: 10.834

5. Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.

Authors: Andrew R Larsen; Ren-Yuan Bai; Jon H Chung; Alexandra Borodovsky; Charles M Rudin; Gregory J Riggins; Fred Bunz
Journal: Mol Cancer Ther Date: 2014-11-05 Impact factor: 6.261

6. Primary cilia cycle in PtK1 cells: effects of colcemid and taxol on cilia formation and resorption.

Authors: C G Jensen; E A Davison; S S Bowser; C L Rieder
Journal: Cell Motil Cytoskeleton Date: 1987

7. Gefitinib, an EGFR Tyrosine Kinase inhibitor, Prevents Smoke-Mediated Ciliated Airway Epithelial Cell Loss and Promotes Their Recovery.

Authors: Monica Valencia-Gattas; Gregory E Conner; Nevis L Fregien
Journal: PLoS One Date: 2016-08-17 Impact factor: 3.240

8. Identification of drugs that restore primary cilium expression in cancer cells.

Authors: Niamat Ali Khan; Nicolas Willemarck; Ali Talebi; Arnaud Marchand; Maria Mercedes Binda; Jonas Dehairs; Natalia Rueda-Rincon; Veerle W Daniels; Muralidhararao Bagadi; Deepak Balaji Thimiri Govinda Raj; Frank Vanderhoydonc; Sebastian Munck; Patrick Chaltin; Johannes V Swinnen
Journal: Oncotarget Date: 2016-03-01

9. Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers.

Authors: Concetta Di Mauro; Roberta Rosa; Valentina D'Amato; Paola Ciciola; Alberto Servetto; Roberta Marciano; Roberta Clara Orsini; Luigi Formisano; Sandro De Falco; Valeria Cicatiello; Maurizio Di Bonito; Monica Cantile; Francesca Collina; Angela Chambery; Bianca Maria Veneziani; Sabino De Placido; Roberto Bianco
Journal: Br J Cancer Date: 2017-04-25 Impact factor: 7.640

10. Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.

Authors: Yangfan P Liu; I-Chun Tsai; Manuela Morleo; Edwin C Oh; Carmen C Leitch; Filomena Massa; Byung-Hoon Lee; David S Parker; Daniel Finley; Norann A Zaghloul; Brunella Franco; Nicholas Katsanis
Journal: J Clin Invest Date: 2014-04-01 Impact factor: 14.808

45 in total

Review 1. Mixed signals from the cell's antennae: primary cilia in cancer.

Authors: Thibaut Eguether; Michael Hahne
Journal: EMBO Rep Date: 2018-10-22 Impact factor: 8.807

2. Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.

Authors: Catherine R Cochrane; Vijesh Vaghjiani; Anette Szczepny; W Samantha N Jayasekara; Alvaro Gonzalez-Rajal; Kazu Kikuchi; Geoffrey W McCaughan; Andrew Burgess; Daniel J Gough; D Neil Watkins; Jason E Cain
Journal: J Clin Invest Date: 2020-08-03 Impact factor: 14.808

3. Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells.

Authors: Maha H Jamal; Ane C F Nunes; Nosratola D Vaziri; Ramani Ramchandran; Robert L Bacallao; Andromeda M Nauli; Surya M Nauli
Journal: Biochem Pharmacol Date: 2020-05-26 Impact factor: 5.858

4. Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs.

Authors: Anna A Kiseleva; Vladislav A Korobeynikov; Anna S Nikonova; Peishan Zhang; Petr Makhov; Alexander Y Deneka; Margret B Einarson; Ilya G Serebriiskii; Hanqing Liu; Jeffrey R Peterson; Erica A Golemis
Journal: Clin Cancer Res Date: 2019-03-13 Impact factor: 12.531