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Literature DB >> 21385728

Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants.

Abstract

Gene knockdown by RNA interference (RNAi) in Caenorhabditis elegans is readily achieved by feeding bacteria expressing double-stranded RNA (dsRNA). Enhanced RNAi (Eri) mutants facilitate RNAi due to their hypersensitivity to dsRNA. Here, we compare eight Eri mutants for sensitivity to ingested dsRNA, targeting a variety of tissue-specific genes.

Entities: Disease Species

Mesh：

Substances：
RNA, Double-Stranded

Year: 2011 PMID： 21385728 PMCID： PMC3120140 DOI： 10.1534/genetics.111.127209

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

13 in total

1. The role of RNA editing by ADARs in RNAi.

Authors: Scott W Knight; Brenda L Bass
Journal: Mol Cell Date: 2002-10 Impact factor: 17.970

2. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.

Authors: Duo Wang; Scott Kennedy; Darryl Conte; John K Kim; Harrison W Gabel; Ravi S Kamath; Craig C Mello; Gary Ruvkun
Journal: Nature Date: 2005-07-28 Impact factor: 49.962

3. Specific interference by ingested dsRNA.

Authors: L Timmons; A Fire
Journal: Nature Date: 1998-10-29 Impact factor: 49.962

4. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.

Authors: Femke Simmer; Marcel Tijsterman; Susan Parrish; Sandhya P Koushika; Michael L Nonet; Andrew Fire; Julie Ahringer; Ronald H A Plasterk
Journal: Curr Biol Date: 2002-08-06 Impact factor: 10.834

5. Enhanced neuronal RNAi in C. elegans using SID-1.

Authors: Andrea Calixto; Dattananda Chelur; Irini Topalidou; Xiaoyin Chen; Martin Chalfie
Journal: Nat Methods Date: 2010-05-30 Impact factor: 28.547

6. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.

Authors: Sylvia E J Fischer; Maurice D Butler; Qi Pan; Gary Ruvkun
Journal: Nature Date: 2008-09-10 Impact factor: 49.962

7. Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans.

Authors: Rosalind C Lee; Christopher M Hammell; Victor Ambros
Journal: RNA Date: 2006-02-17 Impact factor: 4.942

8. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.

Authors: Scott Kennedy; Duo Wang; Gary Ruvkun
Journal: Nature Date: 2004-02-12 Impact factor: 49.962

9. Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction.

Authors: T Gu; S Orita; M Han
Journal: Mol Cell Biol Date: 1998-08 Impact factor: 4.272

10. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans.

Authors: Shane L Rea; Natascia Ventura; Thomas E Johnson
Journal: PLoS Biol Date: 2007-10-02 Impact factor: 8.029

23 in total

Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants.

1. The role of RNA editing by ADARs in RNAi.

2. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.

3. Specific interference by ingested dsRNA.

4. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.

5. Enhanced neuronal RNAi in C. elegans using SID-1.

6. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.

7. Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans.

8. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.

9. Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction.

10. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans.

1. RNAi screening to identify postembryonic phenotypes in C. elegans.

Review 2. From genes to function: the C. elegans genetic toolbox.

3. Assays for direct and indirect effects of C. elegans endo-siRNAs.

4. Vampiric isolation of extracellular fluid from Caenorhabditis elegans.

5. Early Developmental Exposure to dsRNA Is Critical for Initiating Efficient Nuclear RNAi in C. elegans.

6. The nuclear argonaute NRDE-3 contributes to transitive RNAi in Caenorhabditis elegans.

7. GTSF-1 is required for formation of a functional RNA-dependent RNA Polymerase complex in Caenorhabditis elegans.

8. Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decay.

9. PAR-5 is a PARty hub in the germline: Multitask proteins in development and disease.

10. The Influence of Competition Among C. elegans Small RNA Pathways on Development.