BACKGROUND: Numerous reports have documented reduced graft and patient survival after use of hepatitis C (HCV) seropositive allografts in liver transplantation (OLT). We aimed to examine if the use of a HCV+ liver allograft affects patient and graft survivals compared to HCV- donor allografts in a case-controlled analysis of the united network for organ sharing (UNOS) database. METHODS: We examined 63,149 liver transplants (61,905 donors HCV-; 1,244 donors HCV+) from the UNOS standard transplant analysis and research (STAR) file from 1987 to 2007. Donor and recipient demographics and outcomes were collected in which donor HCV serology was complete. A case-controlled cohort from 11 donor and recipient variables comparing donor HCV- and HCV+ allografts (n=540 in each group) was created using propensity scores with a matching algorithm. Graft and patient survival was estimated using Kaplan-Meier survival curves. RESULTS: Significant differences were evident in the unadjusted cohort between recipients who received HCV+ and HCV- allografts, including HCV+ recipients, donor and recipient age, and model for end-stage liver disease (MELD) exception cases. Use of HCV+ allograft resulted in significantly lower graft survival (8.1 vs. 10.6 years; P=0.001) and patient survival (10.2 vs. 12.3 years; P=0.01) after OLT. In the matched cohort, HCV seropositivity had no detrimental effect on the graft (P=0.57) or patient (P=0.78) survival after OLT. CONCLUSIONS: This is the first population-based analysis to show that after adjusting for donor and recipient characteristics there was no difference in graft or patient survival with the use of HCV+ donor liver allografts compared to HCV- donor liver allografts.
BACKGROUND: Numerous reports have documented reduced graft and patient survival after use of hepatitis C (HCV) seropositive allografts in liver transplantation (OLT). We aimed to examine if the use of a HCV+ liver allograft affects patient and graft survivals compared to HCV- donor allografts in a case-controlled analysis of the united network for organ sharing (UNOS) database. METHODS: We examined 63,149 liver transplants (61,905 donors HCV-; 1,244 donors HCV+) from the UNOS standard transplant analysis and research (STAR) file from 1987 to 2007. Donor and recipient demographics and outcomes were collected in which donor HCV serology was complete. A case-controlled cohort from 11 donor and recipient variables comparing donor HCV- and HCV+ allografts (n=540 in each group) was created using propensity scores with a matching algorithm. Graft and patient survival was estimated using Kaplan-Meier survival curves. RESULTS: Significant differences were evident in the unadjusted cohort between recipients who received HCV+ and HCV- allografts, including HCV+ recipients, donor and recipient age, and model for end-stage liver disease (MELD) exception cases. Use of HCV+ allograft resulted in significantly lower graft survival (8.1 vs. 10.6 years; P=0.001) and patient survival (10.2 vs. 12.3 years; P=0.01) after OLT. In the matched cohort, HCV seropositivity had no detrimental effect on the graft (P=0.57) or patient (P=0.78) survival after OLT. CONCLUSIONS: This is the first population-based analysis to show that after adjusting for donor and recipient characteristics there was no difference in graft or patient survival with the use of HCV+ donor liver allografts compared to HCV- donor liver allografts.
Authors: Ergun Velidedeoglu; Niraj M Desai; Louis Campos; Kim M Olthoff; Abraham Shaked; Frederick Nunes; Gillian Zeldin; Charmaine Stewart; Emily Blumberg; John Abrams; James F Markmann Journal: Transplantation Date: 2002-02-27 Impact factor: 4.939
Authors: Norah A Terrault; Mitchell L Shiffman; Anna S F Lok; Sammy Saab; Lan Tong; Robert S Brown; Gregory T Everson; K Rajender Reddy; Jeffrey H Fair; Laura M Kulik; Timothy L Pruett; Leonard B Seeff Journal: Liver Transpl Date: 2007-01 Impact factor: 5.799
Authors: H E Vargas; T Laskus; L F Wang; R Lee; M Radkowski; F Dodson; J J Fung; J Rakela Journal: Gastroenterology Date: 1999-07 Impact factor: 22.682
Authors: R M Ghobrial; R Steadman; J Gornbein; C Lassman; C D Holt; P Chen; D G Farmer; H Yersiz; N Danino; E Collisson; A Baquarizo; S S Han; S Saab; L I Goldstein; J A Donovan; K Esrason; R W Busuttil Journal: Ann Surg Date: 2001-09 Impact factor: 12.969
Authors: Jennifer C Lai; Jacqueline G O'Leary; James F Trotter; Elizabeth C Verna; Robert S Brown; R Todd Stravitz; Jeffrey D Duman; Lisa M Forman; Norah A Terrault Journal: Liver Transpl Date: 2012-05 Impact factor: 5.799
Authors: Glauco Adrieno Westphal; Valter Duro Garcia; Rafael Lisboa de Souza; Cristiano Augusto Franke; Kalinca Daberkow Vieira; Viviane Renata Zaclikevis Birckholz; Miriam Cristine Machado; Eliana Régia Barbosa de Almeida; Fernando Osni Machado; Luiz Antônio da Costa Sardinha; Raquel Wanzuita; Carlos Eduardo Soares Silvado; Gerson Costa; Vera Braatz; Milton Caldeira Filho; Rodrigo Furtado; Luana Alves Tannous; André Gustavo Neves de Albuquerque; Edson Abdala Journal: Rev Bras Ter Intensiva Date: 2016-09
Authors: Ju Dong Yang; Joseph J Larson; Kymberly D Watt; Alina M Allen; Russell H Wiesner; Gregory J Gores; Lewis R Roberts; Julie A Heimbach; Michael D Leise Journal: Clin Gastroenterol Hepatol Date: 2016-12-21 Impact factor: 11.382
Authors: Maria Stepanova; Mehmet Sayiner; Leyla de Avila; Zahra Younoszai; Andrei Racila; Zobair M Younossi Journal: BMC Gastroenterol Date: 2016-11-15 Impact factor: 3.067