Literature DB >> 21353781

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

Michael Weinfeld1, Rajam S Mani, Ismail Abdou, R Daniel Aceytuno, J N Mark Glover.   

Abstract

The termini of DNA strand breaks induced by internal and external factors often require processing before missing nucleotides can be replaced by DNA polymerases and the strands rejoined by DNA ligases. Polynucleotide kinase/phosphatase (PNKP) serves a crucial role in the repair of DNA strand breaks by catalyzing the restoration of 5'-phosphate and 3'-hydroxyl termini. It participates in several DNA repair pathways through interactions with other DNA repair proteins, notably XRCC1 and XRCC4. Recent studies have highlighted the physiological importance of PNKP in maintaining the genomic stability of normal tissues, particularly developing neural cells, as well as enhancing the resistance of cancer cells to genotoxic therapeutic agents.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21353781      PMCID： PMC3134258          DOI： 10.1016/j.tibs.2011.01.006

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  71 in total

1.  Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage.

Authors:  A Jilani; D Ramotar; C Slack; C Ong; X M Yang; S W Scherer; D D Lasko
Journal:  J Biol Chem       Date:  1999-08-20       Impact factor: 5.157

Review 2.  The FHA domain.

Authors:  Daniel Durocher; Stephen P Jackson
Journal:  FEBS Lett       Date:  2002-02-20       Impact factor: 4.124

3.  Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway.

Authors:  Marc Audebert; Bernard Salles; Michael Weinfeld; Patrick Calsou
Journal:  J Mol Biol       Date:  2005-11-28       Impact factor: 5.469

Review 4.  DNA damage, aging, and cancer.

Authors:  Jan H J Hoeijmakers
Journal:  N Engl J Med       Date:  2009-10-08       Impact factor: 91.245

5.  Strand breaks and K' end-groups in DNA of irradiated thymocytes.

Authors:  T Coquerelle; A Bopp; B Kessler; U Hagen
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1973-10

6.  Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe.

Authors:  Maria Meijer; Feridoun Karimi-Busheri; Timothy Y Huang; Michael Weinfeld; Dallan Young
Journal:  J Biol Chem       Date:  2001-11-29       Impact factor: 5.157

7.  Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.

Authors:  E V Koonin; R L Tatusov
Journal:  J Mol Biol       Date:  1994-11-18       Impact factor: 5.469

8.  Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.

Authors:  Christine Anne Koch; Roger Agyei; Sarah Galicia; Pavel Metalnikov; Paul O'Donnell; Andrei Starostine; Michael Weinfeld; Daniel Durocher
Journal:  EMBO J       Date:  2004-09-23       Impact factor: 11.598

9.  Mutations in PNKP cause microcephaly, seizures and defects in DNA repair.

Authors:  Jun Shen; Edward C Gilmore; Christine A Marshall; Mary Haddadin; John J Reynolds; Wafaa Eyaid; Adria Bodell; Brenda Barry; Danielle Gleason; Kathryn Allen; Vijay S Ganesh; Bernard S Chang; Arthur Grix; R Sean Hill; Meral Topcu; Keith W Caldecott; A James Barkovich; Christopher A Walsh
Journal:  Nat Genet       Date:  2010-01-31       Impact factor: 38.330

10.  The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.

Authors:  Joanna I Loizou; Sherif F El-Khamisy; Anastasia Zlatanou; David J Moore; Douglas W Chan; Jun Qin; Stefania Sarno; Flavio Meggio; Lorenzo A Pinna; Keith W Caldecott
Journal:  Cell       Date:  2004-04-02       Impact factor: 41.582
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  90 in total

1.  DNA end processing by polynucleotide kinase/phosphatase.

Authors:  Matthew J Schellenberg; R Scott Williams
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-19       Impact factor: 11.205

2.  Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.

Authors:  Santi M Mandal; Muralidhar L Hegde; Arpita Chatterjee; Pavana M Hegde; Bartosz Szczesny; Dibyendu Banerjee; Istvan Boldogh; Rui Gao; Maria Falkenberg; Claes M Gustafsson; Partha S Sarkar; Tapas K Hazra
Journal:  J Biol Chem       Date:  2011-11-30       Impact factor: 5.157

Review 3.  Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time.

Authors:  Gareth J Williams; Michal Hammel; Sarvan Kumar Radhakrishnan; Dale Ramsden; Susan P Lees-Miller; John A Tainer
Journal:  DNA Repair (Amst)       Date:  2014-03-20

4.  Association of ATM activation and DNA repair with induced radioresistance after low-dose irradiation.

Authors:  L Enns; A Rasouli-Nia; M Hendzel; B Marples; M Weinfeld
Journal:  Radiat Prot Dosimetry       Date:  2015-04-22       Impact factor: 0.972

Review 5.  Looking beneath the surface to determine what makes DNA damage deleterious.

Authors:  Marc M Greenberg
Journal:  Curr Opin Chem Biol       Date:  2014-04-22       Impact factor: 8.822

6.  TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.

Authors:  Jinho Heo; Jing Li; Matthew Summerlin; Annette Hays; Sachin Katyal; Peter J McKinnon; Karin C Nitiss; John L Nitiss; Leslyn A Hanakahi
Journal:  DNA Repair (Amst)       Date:  2015-03-17

Review 7.  Non-homologous end joining: emerging themes and unanswered questions.

Authors:  Sarvan Kumar Radhakrishnan; Nicholas Jette; Susan P Lees-Miller
Journal:  DNA Repair (Amst)       Date:  2014-02-26

8.  PNKP knockdown by RNA interference inhibits herpes simplex virus-1 replication in astrocytes.

Authors:  Lei Yue; Sujie Guo; Xia Cao; Ying Zhang; Le Sun; Longding Liu; Min Yan; Qihan Li
Journal:  Virol Sin       Date:  2013-11-06       Impact factor: 4.327

9.  Progressive cerebellar atrophy and polyneuropathy: expanding the spectrum of PNKP mutations.

Authors:  Cathryn Poulton; Renske Oegema; Daphne Heijsman; Jeannette Hoogeboom; Rachel Schot; Hans Stroink; Michèl A Willemsen; Frans W Verheijen; Peter van de Spek; Andreas Kremer; Grazia M S Mancini
Journal:  Neurogenetics       Date:  2012-12-09       Impact factor: 2.660

10.  XRCC1 Arg399Gln polymorphism contributes to increased risk of colorectal cancer in Chinese population.

Authors:  Zhong Tian; Yi-Ling Li; Jin-Gang Liu
Journal:  Mol Biol Rep       Date:  2013-05-28       Impact factor: 2.316
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