OBJECTIVE: Assess the feasibility of a fetoscopic patch coverage method for myelomeningocele repair in a sheep model. STUDY DESIGN: Experimental study. A myelomeningocele-like defect was created in 15 fetal sheep on day 75 of gestation. Six remained untreated, whereas 9 underwent fetoscopic coverage of the defect on day 95 of gestation using an inert patch secured with surgical sealant. Clinical and histological examinations were performed after delivery. RESULTS: Four valid newborn lambs were obtained in each group. Mean fetoscopic surgical time was 26.9 (SD=7.4)min. All untreated animals had an open lumbar defect with cerebrospinal fluid leakage, paraplegia, urinary incontinence, and Chiari malformation. All treated animals had a closed defect and were able to walk; one had weak bladder control, and another mild Chiari malformation. CONCLUSION: In a chronic myelomeningocele model in fetal sheep, fetoscopic repair using a sealed patch results in simple, fast, satisfactory neural tube closure and averts neurological damage and Chiari malformation.
OBJECTIVE: Assess the feasibility of a fetoscopic patch coverage method for myelomeningocele repair in a sheep model. STUDY DESIGN: Experimental study. A myelomeningocele-like defect was created in 15 fetal sheep on day 75 of gestation. Six remained untreated, whereas 9 underwent fetoscopic coverage of the defect on day 95 of gestation using an inert patch secured with surgical sealant. Clinical and histological examinations were performed after delivery. RESULTS: Four valid newborn lambs were obtained in each group. Mean fetoscopic surgical time was 26.9 (SD=7.4)min. All untreated animals had an open lumbar defect with cerebrospinal fluid leakage, paraplegia, urinary incontinence, and Chiari malformation. All treated animals had a closed defect and were able to walk; one had weak bladder control, and another mild Chiari malformation. CONCLUSION: In a chronic myelomeningocele model in fetal sheep, fetoscopic repair using a sealed patch results in simple, fast, satisfactory neural tube closure and averts neurological damage and Chiari malformation.
Authors: Jose L Peiro; Cesar G Fontecha; Rodrigo Ruano; Marielle Esteves; Carla Fonseca; Mario Marotta; Sina Haeri; Michael A Belfort Journal: Surg Endosc Date: 2013-05-14 Impact factor: 4.584
Authors: Robert Bergholz; Thomas Krebs; Birte Cremieux; Carla Georgi; Felipe Fromm; Michael Boettcher; Thomas Andreas; Bastian Tiemann; Katharina Wenke; Konrad Reinshagen; Kurt Hecher Journal: Surg Endosc Date: 2020-02-18 Impact factor: 4.584
Authors: D A Lapa; R H Chmait; Y Gielchinsky; M Yamamoto; N Persico; M Santorum; M M Gil; L Trigo; R A Quintero; K H Nicolaides Journal: Ultrasound Obstet Gynecol Date: 2021-09-13 Impact factor: 8.678