Literature DB >> 21348876

Impact of conjugated linoleic acid on bone physiology: proposed mechanism involving inhibition of adipogenesis.

Steven W Ing1, Martha A Belury.   

Abstract

Conjugated linoleic acid (CLA) supplementation decreases adipose mass and increases bone mass in mice. Recent clinical studies demonstrate a beneficial effect of CLA on reducing weight and adipose mass in humans. This article reviews possible biological mechanisms of action of CLA on bone metabolism, focusing on modulation of nuclear receptor peroxisome proliferator-activated receptor gamma activity to steer mesenchymal stem cell differentiation toward an adipose and away from an osteoblast lineage. Clinical studies of the effects of CLA on bone mass and clinical implications of the effects of CLA on bone health in humans are summarized and discussed.
© 2011 International Life Sciences Institute.

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Year:  2011        PMID： 21348876      PMCID： PMC3814018          DOI： 10.1111/j.1753-4887.2011.00376.x

Source DB:  PubMed          Journal:  Nutr Rev        ISSN： 0029-6643            Impact factor:   7.110


  90 in total

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7.  Canola Oil in Lactating Dairy Cow Diets Reduces Milk Saturated Fatty Acids and Improves Its Omega-3 and Oleic Fatty Acid Content.

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  10 in total

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