BACKGROUND: The protective effect of physical activity (PA) on abdominal adiposity is unclear. OBJECTIVE: We examined whether PA independently predicted gains in body weight and abdominal adiposity. DESIGN: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status, alcohol consumption, educational level, total energy intake, duration of follow-up, baseline body weight, change in body weight, and waist circumference (when applicable). RESULTS: PA significantly predicted a lower waist circumference (in cm) in men (β = -0.045; 95% CI: -0.057, -0.034) and in women (β = -0.035; 95% CI: -0.056, -0.015) independent of baseline body weight, baseline waist circumference, and other confounding factors. The magnitude of associations was materially unchanged after adjustment for change in body weight. PA was not significantly associated with annual weight gain (in kg) in men (β = -0.008; 95% CI: -0.02, 0.003) and women (β = -0.01; 95% CI: -0.02, 0.0006). The odds of becoming obese were reduced by 7% (P < 0.001) and 10% (P < 0.001) for a one-category difference in baseline PA in men and women, respectively. CONCLUSION: Our results suggest that a higher level of PA reduces abdominal adiposity independent of baseline and changes in body weight and is thus a useful strategy for preventing chronic diseases and premature deaths.
BACKGROUND: The protective effect of physical activity (PA) on abdominal adiposity is unclear. OBJECTIVE: We examined whether PA independently predicted gains in body weight and abdominal adiposity. DESIGN: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status, alcohol consumption, educational level, total energy intake, duration of follow-up, baseline body weight, change in body weight, and waist circumference (when applicable). RESULTS: PA significantly predicted a lower waist circumference (in cm) in men (β = -0.045; 95% CI: -0.057, -0.034) and in women (β = -0.035; 95% CI: -0.056, -0.015) independent of baseline body weight, baseline waist circumference, and other confounding factors. The magnitude of associations was materially unchanged after adjustment for change in body weight. PA was not significantly associated with annual weight gain (in kg) in men (β = -0.008; 95% CI: -0.02, 0.003) and women (β = -0.01; 95% CI: -0.02, 0.0006). The odds of becoming obese were reduced by 7% (P < 0.001) and 10% (P < 0.001) for a one-category difference in baseline PA in men and women, respectively. CONCLUSION: Our results suggest that a higher level of PA reduces abdominal adiposity independent of baseline and changes in body weight and is thus a useful strategy for preventing chronic diseases and premature deaths.
Authors: U Ekelund; E Kolle; J Steene-Johannessen; K E Dalene; A K O Nilsen; S A Anderssen; B H Hansen Journal: Int J Obes (Lond) Date: 2017-08-04 Impact factor: 5.095
Authors: Manja Koch; Jeremy D Furtado; Gordon Z Jiang; Brianna E Gray; Tianxi Cai; Frank Sacks; Anne Tjønneland; Kim Overvad; Majken K Jensen Journal: J Lipid Res Date: 2017-04-01 Impact factor: 5.922
Authors: J M Genkinger; K Wu; M Wang; D Albanes; A Black; P A van den Brandt; K A Burke; M B Cook; S M Gapstur; G G Giles; E Giovannucci; G G Goodman; P J Goodman; N Håkansson; T J Key; S Männistö; L Le Marchand; L M Liao; R J MacInnis; M L Neuhouser; E A Platz; N Sawada; J M Schenk; V L Stevens; R C Travis; S Tsugane; K Visvanathan; L R Wilkens; A Wolk; S A Smith-Warner Journal: Ann Oncol Date: 2020-01 Impact factor: 32.976
Authors: Tricia Peters; Soren Brage; Kate Westgate; Paul W Franks; Anna Gradmark; Maria Jose Tormo Diaz; Jose Maria Huerta; Benedetta Bendinelli; Mattheaus Vigl; Heiner Boeing; Wanda Wendel-Vos; Annemieke Spijkerman; Kristin Benjaminsen-Borch; Elisavet Valanou; Blandine de Lauzon Guillain; Françoise Clavel-Chapelon; Stephen Sharp; Nicola Kerrison; Claudia Langenberg; Larraitz Arriola; Aurelio Barricarte; Carlos Gonzales; Sara Grioni; Rudolf Kaaks; Timothy Key; Kay Tee Khaw; Anne May; Peter Nilsson; Teresa Norat; Kim Overvad; Domenico Palli; Salvatore Panico; Jose Ramón Quirós; Fulvio Ricceri; Maria-Jose Sanchez; Nadia Slimani; Anne Tjonneland; Rosario Tumino; Edith Feskins; Elio Riboli; Ulf Ekelund; Nick Wareham Journal: Eur J Epidemiol Date: 2011-11-17 Impact factor: 8.082