OBJECTIVE: There is growing evidence that circulating microRNAs (miRNAs) play an important role in obesity. However, whether they can contribute to adult weight gain is still unclear. METHODS: In the training set with 40 nonsmoking, healthy women identified from the Mano-A-Mano Mexican American Cohort study, global circulating miRNA profiles in plasma samples were assessed. Cox proportional hazard regression was used to assess the effects of plasma miRNAs on significant weight gain during a 5-year follow-up. Plasma miRNAs associated with significant weight gain were further validated in two testing sets (N = 160 and 100, respectively). RESULTS: A total of 23 significant plasma miRNAs were identified in the training set. Among them, eight were validated in two testing sets. They were miR-142, miR-122, miR-125b, miR-15b, miR-130b, miR222, miR-519d, and miR-31. Using those eight miRNAs, a risk score for significant weight gain was created. Study participants with a high risk score had 3.01-fold increased risk of having significant weight gain in the whole study population (hazard ratio: 3.01, 95% confidence interval: 1.70-5.47). CONCLUSIONS: The findings provide evidence that circulating miRNAs play important roles in obesity and weight gain and suggest new targets for understanding the mechanisms of weight gain and developing weight loss intervention strategies.
OBJECTIVE: There is growing evidence that circulating microRNAs (miRNAs) play an important role in obesity. However, whether they can contribute to adult weight gain is still unclear. METHODS: In the training set with 40 nonsmoking, healthy women identified from the Mano-A-Mano Mexican American Cohort study, global circulating miRNA profiles in plasma samples were assessed. Cox proportional hazard regression was used to assess the effects of plasma miRNAs on significant weight gain during a 5-year follow-up. Plasma miRNAs associated with significant weight gain were further validated in two testing sets (N = 160 and 100, respectively). RESULTS: A total of 23 significant plasma miRNAs were identified in the training set. Among them, eight were validated in two testing sets. They were miR-142, miR-122, miR-125b, miR-15b, miR-130b, miR222, miR-519d, and miR-31. Using those eight miRNAs, a risk score for significant weight gain was created. Study participants with a high risk score had 3.01-fold increased risk of having significant weight gain in the whole study population (hazard ratio: 3.01, 95% confidence interval: 1.70-5.47). CONCLUSIONS: The findings provide evidence that circulating miRNAs play important roles in obesity and weight gain and suggest new targets for understanding the mechanisms of weight gain and developing weight loss intervention strategies.
Authors: Anna Prats-Puig; Francisco J Ortega; Josep M Mercader; José M Moreno-Navarrete; María Moreno; Nuria Bonet; Wifredo Ricart; Abel López-Bermejo; José M Fernández-Real Journal: J Clin Endocrinol Metab Date: 2013-08-08 Impact factor: 5.958
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Authors: Francisco J Ortega; Josep M Mercader; José María Moreno-Navarrete; Oscar Rovira; Ester Guerra; Eduardo Esteve; Gemma Xifra; Cristina Martínez; Wifredo Ricart; Jennifer Rieusset; Sophie Rome; Monika Karczewska-Kupczewska; Marek Straczkowski; José Manuel Fernández-Real Journal: Diabetes Care Date: 2014-01-29 Impact factor: 19.112
Authors: Noémie Travier; Antonio Agudo; Anne M May; Carlos Gonzalez; Jian'an Luan; Nick J Wareham; H Bas Bueno-de-Mesquita; Saskia W van den Berg; Nadia Slimani; Sabina Rinaldi; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Domenico Palli; Sabina Sieri; Amalia Mattiello; Rosario Tumino; Paolo Vineis; Teresa Norat; Dora Romaguera; Laudina Rodriguez; Maria-José Sanchez; Miren Dorronsoro; Aurelio Barricarte; José M Huerta; Tim J Key; Philippos Orfanos; Androniki Naska; Antonia Trichopoulou; Sabina Rohrmann; Rudolf Kaaks; Manuela M Bergmann; Heiner Boeing; Goran Hallmans; Ingegerd Johansson; Jonas Manjer; Björn Lindkvist; Mariane U Jakobsen; Kim Overvad; Anne Tjonneland; Jytte Halkjaer; Eiliv Lund; Toni Braaten; Andreani Odysseos; Elio Riboli; Petra H Peeters Journal: Prev Med Date: 2011-09-12 Impact factor: 4.018
Authors: Annika Steffen; Thorkild I A Sørensen; Sven Knüppel; Noemie Travier; María-José Sánchez; José María Huerta; J Ramón Quirós; Eva Ardanaz; Miren Dorronsoro; Birgit Teucher; Kuanrong Li; H Bas Bueno-de-Mesquita; Daphne van der A; Amalia Mattiello; Domenico Palli; Rosario Tumino; Vittorio Krogh; Paolo Vineis; Antonia Trichopoulou; Philippos Orfanos; Dimitrios Trichopoulos; Bo Hedblad; Peter Wallström; Kim Overvad; Jytte Halkjær; Anne Tjønneland; Guy Fagherazzi; Laureen Dartois; Francesca Crowe; Kay-Tee Khaw; Nick Wareham; Lefkos Middleton; Anne M May; Petra H M Peeters; Heiner Boeing Journal: PLoS One Date: 2013-07-16 Impact factor: 3.240