Literature DB >> 21345763

Update on microbicide research and development - seeking new HIV prevention tools for women.

T Mertenskoetter1, Paulina E Kaptur.   

Abstract

Women and girls are especially vulnerable to HIV infection in sub-Saharan Africa, and in some of those countries, prevalence among young women can be up to 3 times higher than among men of the same age. Effective HIV prevention options for women are clearly needed in this setting. Several ARV-based vaginal microbicides are currently in development for prevention of HIV transmission to women and are discussed here. The concept of pre-exposure prophylaxis for the prevention of HIV transmission to women is introduced.

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Year:  2011        PMID： 21345763      PMCID： PMC3351943          DOI： 10.1186/2047-783x-16-1-1

Source DB:  PubMed          Journal:  Eur J Med Res        ISSN： 0949-2321            Impact factor:   2.175


  31 in total

1.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

2.  Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial.

Authors:  Lut Van Damme; Gita Ramjee; Michel Alary; Bea Vuylsteke; Verapol Chandeying; Helen Rees; Pachara Sirivongrangson; Léonard Mukenge-Tshibaka; Virginie Ettiègne-Traoré; Charn Uaheowitchai; Salim S Abdool Karim; Benoît Mâsse; Jos Perriëns; Marie Laga
Journal:  Lancet       Date:  2002-09-28       Impact factor: 79.321

Review 3.  Microbicides in the prevention of HIV infection: current status and future directions.

Authors:  Jeremy Nuttall
Journal:  Drugs       Date:  2010-07-09       Impact factor: 9.546

4.  Detection of human immunodeficiency virus type 1 genomic RNA in plasma samples by reverse-transcription polymerase chain reaction.

Authors:  P Bagnarelli; S Menzo; A Manzin; M Giacca; P E Varaldo; M Clementi
Journal:  J Med Virol       Date:  1991-06       Impact factor: 2.327

Review 5.  Dual action microbicides: reappraisal of their roles in contraceptive research.

Authors:  Poornima Chandran; Syed N Kabir
Journal:  Reprod Biomed Online       Date:  2009-10-31       Impact factor: 3.828

6.  Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial.

Authors:  Stephanie Skoler-Karpoff; Gita Ramjee; Khatija Ahmed; Lydia Altini; Marlena Gehret Plagianos; Barbara Friedland; Sumen Govender; Alana De Kock; Nazira Cassim; Thesla Palanee; Gregory Dozier; Robin Maguire; Pekka Lahteenmaki
Journal:  Lancet       Date:  2008-12-06       Impact factor: 79.321

7.  Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women.

Authors:  Annalene Nel; Shanique Smythe; Katherine Young; Karl Malcolm; Clare McCoy; Zeda Rosenberg; Joseph Romano
Journal:  J Acquir Immune Defic Syndr       Date:  2009-08-01       Impact factor: 3.731

8.  Safety and availability of dapivirine (TMC120) delivered from an intravaginal ring.

Authors:  J Romano; B Variano; P Coplan; J Van Roey; K Douville; Z Rosenberg; M Temmerman; H Verstraelen; L Van Bortel; S Weyers; M Mitchnick
Journal:  AIDS Res Hum Retroviruses       Date:  2009-05       Impact factor: 2.205

Review 9.  Microbicides and HIV prevention: lessons from the past, looking to the future.

Authors:  Georgina C Morris; Charles J N Lacey
Journal:  Curr Opin Infect Dis       Date:  2010-02       Impact factor: 4.915

10.  The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1.

Authors:  J L Fahey; J M Taylor; R Detels; B Hofmann; R Melmed; P Nishanian; J V Giorgi
Journal:  N Engl J Med       Date:  1990-01-18       Impact factor: 91.245
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  4 in total

1.  Antiviral breadth and combination potential of peptide triazole HIV-1 entry inhibitors.

Authors:  Karyn McFadden; Patricia Fletcher; Fiorella Rossi; Muddagowda Umashankara; Vanessa Pirrone; Srivats Rajagopal; Hosahudya Gopi; Fred C Krebs; Julio Martin-Garcia; Robin J Shattock; Irwin Chaiken
Journal:  Antimicrob Agents Chemother       Date:  2011-11-14       Impact factor: 5.191

2.  In vivo anti-herpes simplex virus activity of a sulfated derivative of Agaricus brasiliensis mycelial polysaccharide.

Authors:  F T G S Cardozo; I V Larsen; E V Carballo; G Jose; R A Stern; R C Brummel; C M Camelini; M J Rossi; C M O Simões; C R Brandt
Journal:  Antimicrob Agents Chemother       Date:  2013-03-18       Impact factor: 5.191

Review 3.  Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.

Authors:  Joel R Courter; Navid Madani; Joseph Sodroski; Arne Schön; Ernesto Freire; Peter D Kwong; Wayne A Hendrickson; Irwin M Chaiken; Judith M LaLonde; Amos B Smith
Journal:  Acc Chem Res       Date:  2014-02-06       Impact factor: 22.384

Review 4.  Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes.

Authors:  Fernando Notario-Pérez; Roberto Ruiz-Caro; María-Dolores Veiga-Ochoa
Journal:  Drug Des Devel Ther       Date:  2017-06-15       Impact factor: 4.162
  4 in total

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