BACKGROUNDS: To evaluate in healthy eyes the interchangeability of retinal thickness measurements resulting from different protocols of Spectralis optical coherence tomography (OCT, Heidelberg Engineering, Germany). METHODS: Three different central volumetric protocols were performed in one session by one single operator in a randomly selected eye of 31 healthy adults (range, 19-30 years): (1) area 6 × 6 mm, 25 scan pattern (SP), (2) area 6 × 6 mm, 49 SP, (3) area 6 × 3 mm, 97 SP. Nine ETDRS areas were analyzed, except outer areas for 97 SP. Interclass correlation coefficients (ICC) and limits of agreement (Bland-Altman) were calculated. RESULTS: Mean minimal foveal thickness was 224.0 ± 15.8 μm and central retinal thickness 280.8 ± 16.5 μm. ICC ranged from 0.973 to 0.993. Ninety-five percent limits of agreement between the protocols were <7 μm in all ETDRS areas. The difference between two measurements never exceeded 9 μm. CONCLUSIONS: Spectralis OCT retinal thickness measurements in healthy subjects showed good protocol interchangeability for all tested protocols. Larger differences are to be expected in eyes with macular pathology.
BACKGROUNDS: To evaluate in healthy eyes the interchangeability of retinal thickness measurements resulting from different protocols of Spectralis optical coherence tomography (OCT, Heidelberg Engineering, Germany). METHODS: Three different central volumetric protocols were performed in one session by one single operator in a randomly selected eye of 31 healthy adults (range, 19-30 years): (1) area 6 × 6 mm, 25 scan pattern (SP), (2) area 6 × 6 mm, 49 SP, (3) area 6 × 3 mm, 97 SP. Nine ETDRS areas were analyzed, except outer areas for 97 SP. Interclass correlation coefficients (ICC) and limits of agreement (Bland-Altman) were calculated. RESULTS: Mean minimal foveal thickness was 224.0 ± 15.8 μm and central retinal thickness 280.8 ± 16.5 μm. ICC ranged from 0.973 to 0.993. Ninety-five percent limits of agreement between the protocols were <7 μm in all ETDRS areas. The difference between two measurements never exceeded 9 μm. CONCLUSIONS: Spectralis OCT retinal thickness measurements in healthy subjects showed good protocol interchangeability for all tested protocols. Larger differences are to be expected in eyes with macular pathology.
Authors: Maciej Wojtkowski; Rainer Leitgeb; Andrzej Kowalczyk; Tomasz Bajraszewski; Adolf F Fercher Journal: J Biomed Opt Date: 2002-07 Impact factor: 3.170
Authors: Lelia A Paunescu; Joel S Schuman; Lori Lyn Price; Paul C Stark; Siobahn Beaton; Hiroshi Ishikawa; Gadi Wollstein; James G Fujimoto Journal: Invest Ophthalmol Vis Sci Date: 2004-06 Impact factor: 4.799
Authors: Christopher Kai-shun Leung; Carol Yim-lui Cheung; Robert N Weinreb; Gary Lee; Dusheng Lin; Chi Pui Pang; Dennis S C Lam Journal: Invest Ophthalmol Vis Sci Date: 2008-04-30 Impact factor: 4.799
Authors: Farzin Forooghian; Catherine Cukras; Catherine B Meyerle; Emily Y Chew; Wai T Wong Journal: Invest Ophthalmol Vis Sci Date: 2008-05-30 Impact factor: 4.799
Authors: Ute E K Wolf-Schnurrbusch; Lala Ceklic; Christian K Brinkmann; Milko E Iliev; Manuel Frey; Simon P Rothenbuehler; Volker Enzmann; Sebastian Wolf Journal: Invest Ophthalmol Vis Sci Date: 2009-02-21 Impact factor: 4.799
Authors: Jennifer I Lim; Ou Tan; Amani A Fawzi; J Jill Hopkins; John H Gil-Flamer; David Huang Journal: Am J Ophthalmol Date: 2008-07-17 Impact factor: 5.258