Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Fixing the model for transcription: the DNA moves, not the polymerase.

Literature DB >> 21326910

Fixing the model for transcription: the DNA moves, not the polymerase.

Argyris Papantonis¹, Peter R Cook.
1. University of Oxford, UK.

Abstract

The traditional model for transcription sees active polymerases tracking along their templates. An alternative (controversial) model has active enzymes immobilized in "factories." Recent evidence supports the idea that the DNA moves, not the polymerase, and points to alternative explanations of how regulatory motifs like enhancers and silencers work.

Entities: Chemical

Keywords: chromatin loops; fixed RNA polymerases; nuclear organization; transcription factories

Mesh：

Substances：

Year: 2011 PMID： 21326910 PMCID： PMC3023647 DOI： 10.4161/trns.2.1.14275

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

27 in total

1. Directed proteomic analysis of the human nucleolus.

Authors: Jens S Andersen; Carol E Lyon; Archa H Fox; Anthony K L Leung; Yun Wah Lam; Hanno Steen; Matthias Mann; Angus I Lamond
Journal: Curr Biol Date: 2002-01-08 Impact factor: 10.834

Review 2. Higher-order genome organization in human disease.

Authors: Tom Misteli
Journal: Cold Spring Harb Perspect Biol Date: 2010-06-30 Impact factor: 10.005

Review 3. Transcription factories: gene expression in unions?

Authors: Heidi Sutherland; Wendy A Bickmore
Journal: Nat Rev Genet Date: 2009-07 Impact factor: 53.242

Review 4. Insulators and promoters: closer than we think.

Authors: Jesse R Raab; Rohinton T Kamakaka
Journal: Nat Rev Genet Date: 2010-05-05 Impact factor: 53.242

5. RNA is synthesized at the nuclear cage.

Authors: D A Jackson; S J McCready; P R Cook
Journal: Nature Date: 1981-08-06 Impact factor: 49.962

6. Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells.

Authors: Stefan Schoenfelder; Tom Sexton; Lyubomira Chakalova; Nathan F Cope; Alice Horton; Simon Andrews; Sreenivasulu Kurukuti; Jennifer A Mitchell; David Umlauf; Daniela S Dimitrova; Christopher H Eskiw; Yanquan Luo; Chia-Lin Wei; Yijun Ruan; James J Bieker; Peter Fraser
Journal: Nat Genet Date: 2009-12-13 Impact factor: 38.330

7. A large fraction of extragenic RNA pol II transcription sites overlap enhancers.

Authors: Francesca De Santa; Iros Barozzi; Flore Mietton; Serena Ghisletti; Sara Polletti; Betsabeh Khoramian Tusi; Heiko Muller; Jiannis Ragoussis; Chia-Lin Wei; Gioacchino Natoli
Journal: PLoS Biol Date: 2010-05-11 Impact factor: 8.029

8. Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene.

Authors: Sue Mei Tan-Wong; Juliet D French; Nicholas J Proudfoot; Melissa A Brown
Journal: Proc Natl Acad Sci U S A Date: 2008-03-28 Impact factor: 11.205

9. Active RNA polymerases: mobile or immobile molecular machines?

Authors: Argyris Papantonis; Joshua D Larkin; Youichiro Wada; Yoshihiro Ohta; Sigeo Ihara; Tatsuhiko Kodama; Peter R Cook
Journal: PLoS Biol Date: 2010-07-13 Impact factor: 8.029

10. Poised transcription factories prime silent uPA gene prior to activation.

Authors: Carmelo Ferrai; Sheila Q Xie; Paolo Luraghi; Davide Munari; Francisco Ramirez; Miguel R Branco; Ana Pombo; Massimo P Crippa
Journal: PLoS Biol Date: 2010-01-05 Impact factor: 8.029

18 in total

1. Dynamic reconfiguration of long human genes during one transcription cycle.

Authors: Joshua D Larkin; Peter R Cook; Argyris Papantonis
Journal: Mol Cell Biol Date: 2012-05-14 Impact factor: 4.272

2. Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells.

Authors: Jiyoti Verma-Gaur; Ali Torkamani; Lana Schaffer; Steven R Head; Nicholas J Schork; Ann J Feeney
Journal: Proc Natl Acad Sci U S A Date: 2012-10-01 Impact factor: 11.205

Fixing the model for transcription: the DNA moves, not the polymerase.

1. Directed proteomic analysis of the human nucleolus.

Review 2. Higher-order genome organization in human disease.

Review 3. Transcription factories: gene expression in unions?

Review 4. Insulators and promoters: closer than we think.

5. RNA is synthesized at the nuclear cage.

6. Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells.

7. A large fraction of extragenic RNA pol II transcription sites overlap enhancers.

8. Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene.

9. Active RNA polymerases: mobile or immobile molecular machines?

10. Poised transcription factories prime silent uPA gene prior to activation.

1. Dynamic reconfiguration of long human genes during one transcription cycle.

2. Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells.

Review 3. Emerging views of genome organization in Archaea.

Review 4. Promoter clearance by RNA polymerase II.

Review 5. Understanding the regulatory and transcriptional complexity of the genome through structure.

Review 6. Transcription factories in the context of the nuclear and genome organization.

7. Comparison of models for the collinearity of hox genes in the developmental axes of vertebrates.

8. Transcription factories.

9. Spatial Organization and Dynamics of Transcription Elongation and Pre-mRNA Processing in Live Cells.

10. Evolutionary constraints favor a biophysical model explaining hox gene collinearity.