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Literature DB >> 21302052

Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice.

Abstract

The unresponsiveness to LPS detected in C57BL/10Cr mice is inherited as a recessive trait and is determined by an autosomal gene linked to theMup-1 locus on chromosome 4. Since no complementation for LPS responsiveness was observed in F(1) hybrid mice between C3H/HeJ and C57BL/10Cr, we conclude that C57BL/10Cr mice carry a defective allele at the sameLps locus, previously identified by the mutation detected in the C3H/HeJ strain.

Entities: Chemical Disease Species

Year: 1978 PMID： 21302052 DOI： 10.1007/BF01843983

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

18 in total

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Journal: Adv Immunol Date: 1975 Impact factor: 3.543

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Journal: J Immunol Date: 1978-02 Impact factor: 5.422

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Journal: Eur J Immunol Date: 1977-05 Impact factor: 5.532

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Journal: Proc Soc Exp Biol Med Date: 1970-10

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Authors: A Coutinho; L Forni; T Watanabe
Journal: Eur J Immunol Date: 1978-01 Impact factor: 5.532

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Authors: A Coutinho; T Meo; T Watanabe
Journal: Scand J Immunol Date: 1977 Impact factor: 3.487

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Journal: J Exp Med Date: 1974-11-01 Impact factor: 14.307

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Authors: J Watson; M Largen; K P McAdam
Journal: J Exp Med Date: 1978-01-01 Impact factor: 14.307

17 in total

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Journal: Mamm Genome Date: 1992 Impact factor: 2.957

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Review 3. TLRs and innate immunity.

Authors: Bruce A Beutler
Journal: Blood Date: 2008-08-29 Impact factor: 22.113

Review 4. Innate immunity and the new forward genetics.

Authors: Bruce Beutler
Journal: Best Pract Res Clin Haematol Date: 2016-10-21 Impact factor: 3.020

5. Genetic analysis of host responses in sepsis.

Authors: Bruce Beutler; Richard J Ulevitch
Journal: Curr Infect Dis Rep Date: 2007-10 Impact factor: 3.725

6. Bacterial induction of beta interferon in mice is a function of the lipopolysaccharide component.

Authors: A Sing; T Merlin; H P Knopf; P J Nielsen; H Loppnow; C Galanos; M A Freudenberg
Journal: Infect Immun Date: 2000-03 Impact factor: 3.441

7. Mice genetically hyporesponsive to lipopolysaccharide (LPS) exhibit a defect in endocytic uptake of LPS and ceramide.

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Authors: Jenny Persson; Russell E Vance
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9. MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state.

Authors: Reuben Saba; Shantel Gushue; Rhiannon L C H Huzarewich; Kathy Manguiat; Sarah Medina; Catherine Robertson; Stephanie A Booth
Journal: PLoS One Date: 2012-02-17 Impact factor: 3.240

10. Innate immune regulation by toll-like receptors in the brain.

Authors: Carina Mallard
Journal: ISRN Neurol Date: 2012-10-14