Literature DB >> 23979753

Human herpesvirus 6 U69 kinase phosphorylates the methylenecyclopropane nucleosides cyclopropavir, MBX 2168, and MBX 1616 to their monophosphates.

Gloria Komazin-Meredith1, Steven C Cardinale, John D Williams, Norton P Peet, Mark N Prichard, Terry L Bowlin.   

Abstract

Dihydroxymethyl and monohydroxymethyl methylenecyclopropane nucleosides are effective inhibitors of both variants of human herpesvirus 6 (HHV-6). We investigated involvement of HHV-6 U69 protein kinase in their mechanism of action. Phosphorylation of the dihydroxymethyl analogue cyclopropavir and monohydroxymethyl nucleosides with either a 6-ether moiety (MBX 2168) or a 6-thioether moiety (MBX 1616) with purified U69 was examined. All three compounds were substrates of this viral kinase and had similar Michaelis-Menten kinetic parameters.

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Year:  2013        PMID： 23979753      PMCID： PMC3811273          DOI： 10.1128/AAC.00978-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

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Authors:  Erik De Clercq; Lieve Naesens
Journal:  J Clin Virol       Date:  2006-12       Impact factor: 3.168

2.  Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts.

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Journal:  J Clin Virol       Date:  2006-12       Impact factor: 3.168

3.  A population-based study of primary human herpesvirus 6 infection.

Authors:  Danielle M Zerr; Amalia S Meier; Stacy S Selke; Lisa M Frenkel; Meei-Li Huang; Anna Wald; Margaret P Rhoads; Long Nguy; Rena Bornemann; Rhoda Ashley Morrow; Lawrence Corey
Journal:  N Engl J Med       Date:  2005-02-24       Impact factor: 91.245

Review 4.  Update on human herpesvirus 6 biology, clinical features, and therapy.

Authors:  Leen De Bolle; Lieve Naesens; Erik De Clercq
Journal:  Clin Microbiol Rev       Date:  2005-01       Impact factor: 26.132

5.  Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro.

Authors:  Stephanie L Williams-Aziz; Caroll B Hartline; Emma A Harden; Shannon L Daily; Mark N Prichard; Nicole L Kushner; James R Beadle; W Brad Wan; Karl Y Hostetler; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2005-09       Impact factor: 5.191

6.  Benzimidazole analogs inhibit human herpesvirus 6.

Authors:  Mark N Prichard; Samuel L Frederick; Shannon Daily; Katherine Z Borysko; Leroy B Townsend; John C Drach; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2011-02-07       Impact factor: 5.191

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Journal:  Antiviral Res       Date:  1995-12       Impact factor: 5.970

8.  Human herpesvirus-6 infection in children. A prospective study of complications and reactivation.

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9.  Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.

Authors:  Mark N Prichard; John D Williams; Gloria Komazin-Meredith; Atiyya R Khan; Nathan B Price; Geraldine M Jefferson; Emma A Harden; Caroll B Hartline; Norton P Peet; Terry L Bowlin
Journal:  Antimicrob Agents Chemother       Date:  2013-05-13       Impact factor: 5.191

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Journal:  Antimicrob Agents Chemother       Date:  2010-06-14       Impact factor: 5.191
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  6 in total

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Authors:  Gloria Komazin-Meredith; Steven C Cardinale; Katelyn Comeau; Kevin J Magalhaes; Caroll B Hartline; John D Williams; Timothy J Opperman; Mark N Prichard; Terry L Bowlin
Journal:  Antiviral Res       Date:  2015-04-07       Impact factor: 5.970

Review 2.  The development of new therapies for human herpesvirus 6.

Authors:  Mark N Prichard; Richard J Whitley
Journal:  Curr Opin Virol       Date:  2014-10-22       Impact factor: 7.090

Review 3.  Laboratory and clinical aspects of human herpesvirus 6 infections.

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Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

4.  Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions.

Authors:  Gloria Komazin-Meredith; Sunwen Chou; Mark N Prichard; Caroll B Hartline; Steven C Cardinale; Katelyn Comeau; John D Williams; Atiyya R Khan; Norton P Peet; Terry L Bowlin
Journal:  Antimicrob Agents Chemother       Date:  2013-10-21       Impact factor: 5.191

5.  Filociclovir Is a Potent In Vitro and In Vivo Inhibitor of Human Adenoviruses.

Authors:  Karoly Toth; Islam T M Hussein; Ann E Tollefson; Baoling Ying; Jacqueline F Spencer; Jessica Eagar; Scott H James; Mark N Prichard; William S M Wold; Terry L Bowlin
Journal:  Antimicrob Agents Chemother       Date:  2020-10-20       Impact factor: 5.191

Review 6.  Critical Review of Synthesis, Toxicology and Detection of Acyclovir.

Authors:  Yan-Ping Wei; Liang-Yuan Yao; Yi-Yong Wu; Xia Liu; Li-Hong Peng; Ya-Ling Tian; Jian-Hua Ding; Kang-Hua Li; Quan-Guo He
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  6 in total

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