OBJECTIVE: The objective of this research was to study the effect of optic neuritis (ON) on axonal damage in multiple sclerosis (MS) patients. Specifically, we compared changes over 2 years in the retinal nerve fibre layer (RNFL) between affected and contralateral eyes in MS patients with a prior history of ON. METHODS: Thirty-four patients with one unilateral definitive episode of ON were included and underwent a complete ophthalmic examination, optical coherence tomography (OCT), scanning laser polarimetry, visual evoked potentials (VEP) and pattern electroretinogram (pERG). All patients were re-evaluated at 12 and 24 months. Parameters were compared between ON-affected and contralateral eyes in an initial exploration and over the course of the follow-up. Correlations between parameter changes were analysed. RESULTS: RNFL thickness and functional parameters showed more affection in ON eyes (p ≤ 0.05), but changes in measurements during the study were similar between both groups of eyes. CONCLUSIONS: Progressive axonal loss can be detected in the optic nerve, but ON is not a risk factor for increased chronic damage in MS patients without ophthalmic relapses. Loss of the RNFL is caused by progressive degeneration associated with the disease.
OBJECTIVE: The objective of this research was to study the effect of optic neuritis (ON) on axonal damage in multiple sclerosis (MS) patients. Specifically, we compared changes over 2 years in the retinal nerve fibre layer (RNFL) between affected and contralateral eyes in MSpatients with a prior history of ON. METHODS: Thirty-four patients with one unilateral definitive episode of ON were included and underwent a complete ophthalmic examination, optical coherence tomography (OCT), scanning laser polarimetry, visual evoked potentials (VEP) and pattern electroretinogram (pERG). All patients were re-evaluated at 12 and 24 months. Parameters were compared between ON-affected and contralateral eyes in an initial exploration and over the course of the follow-up. Correlations between parameter changes were analysed. RESULTS: RNFL thickness and functional parameters showed more affection in ON eyes (p ≤ 0.05), but changes in measurements during the study were similar between both groups of eyes. CONCLUSIONS: Progressive axonal loss can be detected in the optic nerve, but ON is not a risk factor for increased chronic damage in MSpatients without ophthalmic relapses. Loss of the RNFL is caused by progressive degeneration associated with the disease.
Authors: T Sartoretti; E Sartoretti; S Rauch; C Binkert; M Wyss; D Czell; S Sartoretti-Schefer Journal: AJNR Am J Neuroradiol Date: 2017-06-29 Impact factor: 3.825
Authors: M Satue; E Garcia-Martin; I Fuertes; S Otin; R Alarcia; R Herrero; M P Bambo; L E Pablo; F J Fernandez Journal: Eye (Lond) Date: 2013-02-22 Impact factor: 3.775
Authors: Timm Oberwahrenbrock; Sven Schippling; Marius Ringelstein; Falko Kaufhold; Hanna Zimmermann; Nazmiye Keser; Kim Lea Young; Jens Harmel; Hans-Peter Hartung; Roland Martin; Friedemann Paul; Orhan Aktas; Alexander U Brandt Journal: Mult Scler Int Date: 2012-07-25