PURPOSE: To demonstrate axonal loss in the retinal nerve fiber layer (RNFL) of patients with Parkinson's disease (PD) and to evaluate the ability of Fourier-domain optical coherence tomography (OCT) to detect RNFL degeneration and retinal thinning in these patients. METHODS: PD patients (n=100) and healthy subjects (n=100) were included in the study and underwent visual acuity, color vision, and OCT examinations using two next-generation Fourier-domain devices (Spectralis and Cirrus). Differences in the RNFL thicknesses were compared between patients and controls. RESULTS: RNFL thicknesses were significantly reduced in PD patients compared with healthy subjects, especially those obtained using the Spectralis OCT, in the inferotemporal quadrant (155.6±16.5 μm in healthy eyes vs 142.1±24.9 μm in patients, P=0.040) and in the superotemporal quadrant (142.6±20.9 μm in healthy eyes vs 132.77±18.6 μm in PD patients, P=0.046). Significant differences were observed between controls and patients in relation to mean macular thickness (P=0.031), foveal thickness (P=0.030), and inferior outer thickness (P=0.019). CONCLUSION: PD is associated with RNFL loss and retinal thinning, which is detectable by Fourier-domain OCT measurements.
PURPOSE: To demonstrate axonal loss in the retinal nerve fiber layer (RNFL) of patients with Parkinson's disease (PD) and to evaluate the ability of Fourier-domain optical coherence tomography (OCT) to detect RNFL degeneration and retinal thinning in these patients. METHODS:PDpatients (n=100) and healthy subjects (n=100) were included in the study and underwent visual acuity, color vision, and OCT examinations using two next-generation Fourier-domain devices (Spectralis and Cirrus). Differences in the RNFL thicknesses were compared between patients and controls. RESULTS: RNFL thicknesses were significantly reduced in PDpatients compared with healthy subjects, especially those obtained using the Spectralis OCT, in the inferotemporal quadrant (155.6±16.5 μm in healthy eyes vs 142.1±24.9 μm in patients, P=0.040) and in the superotemporal quadrant (142.6±20.9 μm in healthy eyes vs 132.77±18.6 μm in PDpatients, P=0.046). Significant differences were observed between controls and patients in relation to mean macular thickness (P=0.031), foveal thickness (P=0.030), and inferior outer thickness (P=0.019). CONCLUSION:PD is associated with RNFL loss and retinal thinning, which is detectable by Fourier-domain OCT measurements.
Authors: Elena Garcia-Martin; Victoria Pueyo; Isabel Pinilla; Jose-Ramon Ara; Jesus Martin; Javier Fernandez Journal: Invest Ophthalmol Vis Sci Date: 2011-06-13 Impact factor: 4.799
Authors: Elena Garcia-Martin; Luis E Pablo; Raquel Herrero; Maria Satue; Vicente Polo; Jose M Larrosa; Jesus Martin; Javier Fernandez Journal: Ophthalmology Date: 2012-04-04 Impact factor: 12.079
Authors: Vera L Bonilha; Brent A Bell; Mary E Rayborn; Ivy S Samuels; Anna King; Joe G Hollyfield; Chengsong Xie; Huaibin Cai Journal: Free Radic Biol Med Date: 2017-01-11 Impact factor: 7.376
Authors: V Polo; E Garcia-Martin; M P Bambo; J Pinilla; J M Larrosa; M Satue; S Otin; L E Pablo Journal: Eye (Lond) Date: 2014-03-14 Impact factor: 3.775