Literature DB >> 21289871

MicroRNA-based Cancer Therapeutics: Big Hope from Small RNAs.

Arun Bhardwaj1, Seema Singh, Ajay P Singh.   

Abstract

Tremendous progress has been made during the last few years in identification of novel tumor-associated microRNAs and experimental validation of their cancer relevant gene targets. Indeed, these small non-coding RNAs are now known to modulate many biological pathways related to cancer progression, metastasis and therapy-resistance. Therefore, modulating miRNA functions may provide novel therapeutic opportunities for cancer treatment. This article reviews recent literature on the role of miRNAs in cancer with an emphasis on their potential as cancer therapeutics.

Entities:  

Year:  2010        PMID： 21289871      PMCID： PMC3031298          DOI： 10.4255/mcpharmacol.10.27

Source DB:  PubMed          Journal:  Mol Cell Pharmacol        ISSN： 1938-1247


  50 in total

Review 1.  Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?

Authors:  J Weiler; J Hunziker; J Hall
Journal:  Gene Ther       Date:  2006-03       Impact factor: 5.250

2.  Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.

Authors:  Wen-Yee Choi; Antonio J Giraldez; Alexander F Schier
Journal:  Science       Date:  2007-08-30       Impact factor: 47.728

3.  Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells.

Authors:  Yohei Shimono; Maider Zabala; Robert W Cho; Neethan Lobo; Piero Dalerba; Dalong Qian; Maximilian Diehn; Huiping Liu; Sarita P Panula; Eric Chiao; Frederick M Dirbas; George Somlo; Renee A Reijo Pera; Kaiqin Lao; Michael F Clarke
Journal:  Cell       Date:  2009-08-07       Impact factor: 41.582

4.  A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

Authors:  P Mathijs Voorhoeve; Carlos le Sage; Mariette Schrier; Ad J M Gillis; Hans Stoop; Remco Nagel; Ying-Poi Liu; Josyanne van Duijse; Jarno Drost; Alexander Griekspoor; Eitan Zlotorynski; Norikazu Yabuta; Gabriella De Vita; Hiroshi Nojima; Leendert H J Looijenga; Reuven Agami
Journal:  Cell       Date:  2006-03-24       Impact factor: 41.582

5.  RAS is regulated by the let-7 microRNA family.

Authors:  Steven M Johnson; Helge Grosshans; Jaclyn Shingara; Mike Byrom; Rich Jarvis; Angie Cheng; Emmanuel Labourier; Kristy L Reinert; David Brown; Frank J Slack
Journal:  Cell       Date:  2005-03-11       Impact factor: 41.582

6.  Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival.

Authors:  Junichi Takamizawa; Hiroyuki Konishi; Kiyoshi Yanagisawa; Shuta Tomida; Hirotaka Osada; Hideki Endoh; Tomoko Harano; Yasushi Yatabe; Masato Nagino; Yuji Nimura; Tetsuya Mitsudomi; Takashi Takahashi
Journal:  Cancer Res       Date:  2004-06-01       Impact factor: 12.701

7.  Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.

Authors:  Meritxell Gironella; Mylène Seux; Min-Jue Xie; Carla Cano; Richard Tomasini; Julien Gommeaux; Stephane Garcia; Jonathan Nowak; Man Lung Yeung; Kuan-Teh Jeang; Amandine Chaix; Ladan Fazli; Yoshiharu Motoo; Qing Wang; Palma Rocchi; Antonio Russo; Martin Gleave; Jean-Charles Dagorn; Juan L Iovanna; Alice Carrier; Marie-Josèphe Pébusque; Nelson J Dusetti
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-02       Impact factor: 11.205

8.  Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells.

Authors:  Yiwei Li; Timothy G VandenBoom; Dejuan Kong; Zhiwei Wang; Shadan Ali; Philip A Philip; Fazlul H Sarkar
Journal:  Cancer Res       Date:  2009-08-04       Impact factor: 12.701

9.  miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells.

Authors:  Dejuan Kong; Yiwei Li; Zhiwei Wang; Sanjeev Banerjee; Aamir Ahmad; Hyeong-Reh Choi Kim; Fazlul H Sarkar
Journal:  Stem Cells       Date:  2009-08       Impact factor: 6.277

Review 10.  MicroRNAs: key regulators of stem cells.

Authors:  Vamsi K Gangaraju; Haifan Lin
Journal:  Nat Rev Mol Cell Biol       Date:  2009-02       Impact factor: 94.444
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  39 in total

Review 1.  Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes.

Authors:  Rammohan Devulapally; Ramasamy Paulmurugan
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2013-08-31

2.  Modulation of MicroRNAs by Chemical Carcinogens and Anticancer Drugs in Human Cancer: Potential Inkling to Therapeutic Advantage.

Authors:  Subrata Haldar; Aruna Basu
Journal:  Mol Cell Pharmacol       Date:  2011-01-01

3.  Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors.

Authors:  Myrna Hurtado; Umesh T Sankpal; Aboubacar Kaba; Shahela Mahammad; Jaya Chhabra; Deondra T Brown; Raj K Gurung; Alvin A Holder; Jamboor K Vishwanatha; Riyaz Basha
Journal:  Cell Physiol Biochem       Date:  2018-11-30

4.  Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease.

Authors:  Fanlin Meng; Enyu Dai; Xuexin Yu; Yan Zhang; Xiaowen Chen; Xinyi Liu; Shuyuan Wang; Lihua Wang; Wei Jiang
Journal:  J R Soc Interface       Date:  2013-12-18       Impact factor: 4.118

Review 5.  MicroRNAs in pancreatic malignancy: progress and promises.

Authors:  Sanjeev K Srivastava; Sumit Arora; Seema Singh; Arun Bhardwaj; Courey Averett; Ajay P Singh
Journal:  Cancer Lett       Date:  2014-02-20       Impact factor: 8.679

6.  A carbon dot and molecular beacon based fluorometric sensor for the cancer marker microRNA-21.

Authors:  Mohamad Mahani; Zhahra Mousapour; Faten Divsar; Alireza Nomani; Huangxian Ju
Journal:  Mikrochim Acta       Date:  2019-02-01       Impact factor: 5.833

7.  MicroRNAs as potential clinical biomarkers: emerging approaches for their detection.

Authors:  S K Srivastava; A Bhardwaj; S J Leavesley; W E Grizzle; S Singh; A P Singh
Journal:  Biotech Histochem       Date:  2013-01-07       Impact factor: 1.718

8.  MicroRNA-195 inhibits proliferation of cervical cancer cells by targeting cyclin D1a.

Authors:  Ning Wang; Heng Wei; Duo Yin; Yanming Lu; Yao Zhang; Qiao Zhang; Xiaoxin Ma; Shulan Zhang
Journal:  Tumour Biol       Date:  2015-10-28

9.  Insights into the Role of microRNAs in Pancreatic Cancer Pathogenesis: Potential for Diagnosis, Prognosis, and Therapy.

Authors:  Mohammad Aslam Khan; Haseeb Zubair; Sanjeev Kumar Srivastava; Seema Singh; Ajay Pratap Singh
Journal:  Adv Exp Med Biol       Date:  2015       Impact factor: 2.622

10.  Arginine-rich, cell penetrating peptide-anti-microRNA complexes decrease glioblastoma migration potential.

Authors:  Yu Zhang; Melanie Köllmer; Jason S Buhrman; Mary Y Tang; Richard A Gemeinhart
Journal:  Peptides       Date:  2014-06-23       Impact factor: 3.750
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