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Literature DB >> 21289485

Smad-mediated miRNA processing: a critical role for a conserved RNA sequence.

Abstract

microRNAs (miRNAs) are short, 21-24 nucleotide (nt), non-coding RNAs that post-transcriptionally regulate the expression of messenger RNAs (mRNAs). Through the regulation of their cognate mRNAs, miRNAs control diverse aspects of biology, including development, cellular differentiation, proliferation, metabolism, and death. Thus, miRNAs play a critical role in the determination of normal cellular physiology and misexpression of miRNAs leads to pathological responses. Understanding the mechanisms that control miRNA expression is an important step forward as novel functions of miRNAs continue to be uncovered. In addition to transcriptional regulation, multiple pathways of post-transcriptional modulation of miRNA expression have been uncovered. In this review we discuss the role of the Smads in the regulation of miRNA processing in response to Transforming Growth Factor-β stimulation.

Entities: Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 21289485 PMCID： PMC3230544 DOI： 10.4161/rna.8.1.14299

Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652

35 in total

Review 1. Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

Authors: Yigong Shi; Joan Massagué
Journal: Cell Date: 2003-06-13 Impact factor: 41.582

2. MicroRNA genes are transcribed by RNA polymerase II.

Authors: Yoontae Lee; Minju Kim; Jinju Han; Kyu-Hyun Yeom; Sanghyuk Lee; Sung Hee Baek; V Narry Kim
Journal: EMBO J Date: 2004-09-16 Impact factor: 11.598

Review 3. The widespread regulation of microRNA biogenesis, function and decay.

Authors: Jacek Krol; Inga Loedige; Witold Filipowicz
Journal: Nat Rev Genet Date: 2010-07-27 Impact factor: 53.242

4. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.

Authors: R F Ketting; S E Fischer; E Bernstein; T Sijen; G J Hannon; R H Plasterk
Journal: Genes Dev Date: 2001-10-15 Impact factor: 11.361

Review 5. Smad transcription factors.

Authors: Joan Massagué; Joan Seoane; David Wotton
Journal: Genes Dev Date: 2005-12-01 Impact factor: 11.361

6. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.

Authors: Brandi N Davis; Aaron C Hilyard; Peter H Nguyen; Giorgio Lagna; Akiko Hata
Journal: Mol Cell Date: 2010-08-13 Impact factor: 17.970

7. Modulation of microRNA processing by p53.

Authors: Hiroshi I Suzuki; Kaoru Yamagata; Koichi Sugimoto; Takashi Iwamoto; Shigeaki Kato; Kohei Miyazono
Journal: Nature Date: 2009-07-23 Impact factor: 49.962

8. SMAD proteins control DROSHA-mediated microRNA maturation.

Authors: Brandi N Davis; Aaron C Hilyard; Giorgio Lagna; Akiko Hata
Journal: Nature Date: 2008-06-11 Impact factor: 49.962

9. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.

Authors: Michele Trabucchi; Paola Briata; Mariaflor Garcia-Mayoral; Astrid D Haase; Witold Filipowicz; Andres Ramos; Roberto Gherzi; Michael G Rosenfeld
Journal: Nature Date: 2009-05-20 Impact factor: 49.962

Review 10. DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.

Authors: Frances V Fuller-Pace
Journal: Nucleic Acids Res Date: 2006-08-25 Impact factor: 16.971

16 in total

1. Effect of human TGF-β on the gene expression profile of Schistosoma mansoni adult worms.

Authors: Katia C Oliveira; Mariana L P Carvalho; Sergio Verjovski-Almeida; Philip T LoVerde
Journal: Mol Biochem Parasitol Date: 2012-02-25 Impact factor: 1.759

Review 2. The Regulatory Effects of Transforming Growth Factor-β on Nerve Regeneration.

Authors: Shiying Li; Xiaosong Gu; Sheng Yi
Journal: Cell Transplant Date: 2016-11-23 Impact factor: 4.064

Review 3. Functions of the bone morphogenetic protein signaling pathway through non-coding RNAs.

Authors: Ural Mukhametov; Sergey Lyulin; Dmitry Borzunov; Galina Sufianova; Alina Shumadalova; Daming Zhang; Ilgiz Gareev
Journal: Noncoding RNA Res Date: 2022-07-09

Review 4. Targeting the TGFβ signalling pathway in disease.

Authors: Rosemary J Akhurst; Akiko Hata
Journal: Nat Rev Drug Discov Date: 2012-09-24 Impact factor: 84.694

5. Muscle microRNA signatures as biomarkers of disease progression in amyotrophic lateral sclerosis.

Authors: Ying Si; Xianqin Cui; David K Crossman; Jiaying Hao; Mohamed Kazamel; Yuri Kwon; Peter H King
Journal: Neurobiol Dis Date: 2018-02-24 Impact factor: 5.996

6. Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system.

Authors: Jacqueline R Kemp; Hamiyet Unal; Russell Desnoyer; Hong Yue; Anushree Bhatnagar; Sadashiva S Karnik
Journal: J Mol Cell Cardiol Date: 2014-06-27 Impact factor: 5.000

7. Transforming growth factor β receptor type 1 is essential for female reproductive tract integrity and function.

Authors: Qinglei Li; Julio E Agno; Mark A Edson; Ankur K Nagaraja; Takashi Nagashima; Martin M Matzuk
Journal: PLoS Genet Date: 2011-10-20 Impact factor: 5.917

8. TGF-β and iron differently alter HBV replication in human hepatocytes through TGF-β/BMP signaling and cellular microRNA expression.

Authors: Sun O Park; Mukesh Kumar; Sanjeev Gupta
Journal: PLoS One Date: 2012-06-18 Impact factor: 3.240

Review 9. Transforming growth factor β signaling in uterine development and function.

Authors: Qinglei Li
Journal: J Anim Sci Biotechnol Date: 2014-11-14

10. Role of deregulated microRNAs in breast cancer progression using FFPE tissue.

Authors: Liang Chen; Youhuai Li; Yebo Fu; Jin Peng; Meng-Hsuan Mo; Michael Stamatakos; Christine B Teal; Rachel F Brem; Alexander Stojadinovic; Michael Grinkemeyer; Timothy A McCaffrey; Yan-gao Man; Sidney W Fu
Journal: PLoS One Date: 2013-01-23 Impact factor: 3.240