Literature DB >> 21276450

AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1.

Natalia A Lebedeva1, Nadejda I Rechkunova, Olga I Lavrik.   

Abstract

APE-independent base excision repair (BER) pathway plays an important role in the regulation of DNA repair mechanisms. In this study it has been found that recently discovered tyrosyl-DNA phosphodiesterase 1 (Tdp1) catalyzes the AP site cleavage reaction to generate breaks with the 3'- and 5'-phosphate termini. The removal of the 3'-phosphate is performed by polynucleotide kinase phosphatase (PNKP). Tdp1 is known to interact stably with BER proteins: DNA polymerase beta (Pol β), XRCC1, PARP1 and DNA ligase III. The data suggest a role of Tdp1 in the new APE-independent BER pathway in mammals.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21276450     DOI： 10.1016/j.febslet.2011.01.032

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  35 in total

1.  Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.

Authors:  Junko Murai; Shar-yin N Huang; Benu Brata Das; Thomas S Dexheimer; Shunichi Takeda; Yves Pommier
Journal:  J Biol Chem       Date:  2012-02-27       Impact factor: 5.157

Review 2.  Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

Authors:  Yves Pommier; Shar-yin N Huang; Rui Gao; Benu Brata Das; Junko Murai; Christophe Marchand
Journal:  DNA Repair (Amst)       Date:  2014-05-22

3.  Molecular dynamics of pre-germinative metabolism in primed eggplant (Solanum melongena L.) seeds.

Authors:  Chiara Forti; Valentino Ottobrino; Laura Bassolino; Laura Toppino; Giuseppe Leonardo Rotino; Andrea Pagano; Anca Macovei; Alma Balestrazzi
Journal:  Hortic Res       Date:  2020-06-01       Impact factor: 6.793

4.  Repair of apurinic/apyrimidinic sites in single-stranded DNA initiated by tyrosyl-DNA phosphodiesterase 1.

Authors:  N A Lebedeva; N I Rechkunova; O I Lavrik
Journal:  Dokl Biochem Biophys       Date:  2014-05-03       Impact factor: 0.788

Review 5.  Coordination of DNA single strand break repair.

Authors:  Rachel Abbotts; David M Wilson
Journal:  Free Radic Biol Med       Date:  2016-11-24       Impact factor: 7.376

Review 6.  Neurological disorders associated with DNA strand-break processing enzymes.

Authors:  Bingcheng Jiang; J N Mark Glover; Michael Weinfeld
Journal:  Mech Ageing Dev       Date:  2016-07-25       Impact factor: 5.432

7.  Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage.

Authors:  Evan Q Comeaux; Selma M Cuya; Kyoko Kojima; Nauzanene Jafari; Keith C Wanzeck; James A Mobley; Mary-Ann Bjornsti; Robert C A M van Waardenburg
Journal:  J Biol Chem       Date:  2015-01-21       Impact factor: 5.157

8.  Dehydroabietylamine-based thiazolidin-4-ones and 2-thioxoimidazolidin-4-ones as novel tyrosyl-DNA phosphodiesterase 1 inhibitors.

Authors:  Kseniya Kovaleva; Evgeniya Mamontova; Olga Yarovaya; Olga Zakharova; Alexandra Zakharenko; Olga Lavrik; Nariman Salakhutdinov
Journal:  Mol Divers       Date:  2020-08-24       Impact factor: 2.943

Review 9.  DNA repair abnormalities leading to ataxia: shared neurological phenotypes and risk factors.

Authors:  Edward C Gilmore
Journal:  Neurogenetics       Date:  2014-07-20       Impact factor: 2.660

10.  Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3'- and 5'-phosphodiester-DNA bond cleavage.

Authors:  Evgeny Kiselev; Thomas S Dexheimer; Christophe Marchand; Shar-Yin Naomi Huang; Yves Pommier
Journal:  DNA Repair (Amst)       Date:  2018-05-02
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