PURPOSE: To demonstrate the feasibility of rapid and reliable geometric characterization of normal carotid bifurcation geometry from routine 3D contrast-enhanced magnetic resonance (MR) angiograms. MATERIALS AND METHODS: Repeat scans of 61 participants, acquired as part of the Atherosclerosis Risk in Communities (ARIC) Carotid MRI substudy, were digitally segmented using automated 3D level set methods, relying on an operator only to select the branch endpoints and thresholds for the 3D lumen surface initialization. Geometric factors characterizing the 3D lumen geometry were then extracted automatically. RESULTS: Of 122 scans, 117 could be segmented within 5 minutes each, with 40% being of sufficiently high quality to require less than 2 minutes each. Irrespective of scan quality, geometric factors were found to be highly reproducible, with intraclass correlation coefficients (ICCs) typically above 0.9. The reconstructed lumen surfaces were reproducible to <0.3 mm on average, comparable to previous MRI-based reproducibility studies. Owing to the automated nature of the analysis, operator reliability was near-perfect (ICC >0.99), with lumen surface differences <0.1 mm. CONCLUSION: The 3D geometry of the carotid bifurcation can be characterized rapidly and with a high degree of consistency, even for suboptimal image qualities. This bodes well for large-scale retrospective or prospective studies aimed at teasing out the influence of local vs. systemic risk factors for early atherosclerosis.
PURPOSE: To demonstrate the feasibility of rapid and reliable geometric characterization of normal carotid bifurcation geometry from routine 3D contrast-enhanced magnetic resonance (MR) angiograms. MATERIALS AND METHODS: Repeat scans of 61 participants, acquired as part of the Atherosclerosis Risk in Communities (ARIC) Carotid MRI substudy, were digitally segmented using automated 3D level set methods, relying on an operator only to select the branch endpoints and thresholds for the 3D lumen surface initialization. Geometric factors characterizing the 3D lumen geometry were then extracted automatically. RESULTS: Of 122 scans, 117 could be segmented within 5 minutes each, with 40% being of sufficiently high quality to require less than 2 minutes each. Irrespective of scan quality, geometric factors were found to be highly reproducible, with intraclass correlation coefficients (ICCs) typically above 0.9. The reconstructed lumen surfaces were reproducible to <0.3 mm on average, comparable to previous MRI-based reproducibility studies. Owing to the automated nature of the analysis, operator reliability was near-perfect (ICC >0.99), with lumen surface differences <0.1 mm. CONCLUSION: The 3D geometry of the carotid bifurcation can be characterized rapidly and with a high degree of consistency, even for suboptimal image qualities. This bodes well for large-scale retrospective or prospective studies aimed at teasing out the influence of local vs. systemic risk factors for early atherosclerosis.
Authors: Anitha Varghese; Lindsey A Crowe; Raad H Mohiaddin; Peter D Gatehouse; Guang Zhong Yang; David M Nott; James M McCall; David N Firmin; Dudley J Pennell Journal: J Magn Reson Imaging Date: 2005-02 Impact factor: 4.813
Authors: Michael Markl; Felix Wegent; Timo Zech; Simon Bauer; Christoph Strecker; Martin Schumacher; Cornelius Weiller; Jürgen Hennig; Andreas Harloff Journal: Circ Cardiovasc Imaging Date: 2010-09-16 Impact factor: 7.792
Authors: Chengcheng Zhu; Andrew J Patterson; Owen M Thomas; Umar Sadat; Martin J Graves; Jonathan H Gillard Journal: Int J Cardiovasc Imaging Date: 2012-11-08 Impact factor: 2.357
Authors: Yannis Papaharilaou; Nicolas Aristokleous; Ioannis Seimenis; Mohammad Iman Khozeymeh; Georgios C Georgiou; Brigitta C Brott; Elena Eracleous; Andreas S Anayiotos Journal: Med Biol Eng Comput Date: 2012-11-10 Impact factor: 2.602