BACKGROUND AND PURPOSE: Animal models provide a mechanism for fundamental studies of the coupling between hemodynamics and pathophysiology in diseases such as saccular aneurysms. In this work, we evaluated the capability of an elastase-induced saccular aneurysm model in rabbits to reproduce the anatomic and hemodynamic features typical for human intracranial aneurysms. MATERIALS AND METHODS: Saccular aneurysms were created in 51 rabbits at the origin of the RCCA. Twelve weeks' postcreation, the lumen geometry of the aneurysm and surrounding vasculature was acquired by using 3DRA. Geometric features of these models were measured. Pulsatile 3D CFD studies were performed with rabbit-specific inlet profiles. RESULTS: Geometric features, including aneurysm height, width, neck diameter, aspect ratio, and NSI of all 51 rabbit aneurysm models fell within the range reported for human IAs. The distribution and range in values of pressure, WSS, and OSI were also typical for human IAs. A single recirculation region was observed in 33 (65%) of 51 cases, whereas a second transient recirculation zone was observed in 18 (35%) cases. Both of these flow types are commonly observed in human IAs. CONCLUSIONS: Most hemodynamic and geometric features in a commonly used elastase-induced rabbit saccular aneurysm model are qualitatively and quantitatively similar to those seen in large numbers of human cerebral aneurysms.
BACKGROUND AND PURPOSE: Animal models provide a mechanism for fundamental studies of the coupling between hemodynamics and pathophysiology in diseases such as saccular aneurysms. In this work, we evaluated the capability of an elastase-induced saccular aneurysm model in rabbits to reproduce the anatomic and hemodynamic features typical for humanintracranial aneurysms. MATERIALS AND METHODS:Saccular aneurysms were created in 51 rabbits at the origin of the RCCA. Twelve weeks' postcreation, the lumen geometry of the aneurysm and surrounding vasculature was acquired by using 3DRA. Geometric features of these models were measured. Pulsatile 3D CFD studies were performed with rabbit-specific inlet profiles. RESULTS: Geometric features, including aneurysm height, width, neck diameter, aspect ratio, and NSI of all 51 rabbit aneurysm models fell within the range reported for human IAs. The distribution and range in values of pressure, WSS, and OSI were also typical for human IAs. A single recirculation region was observed in 33 (65%) of 51 cases, whereas a second transient recirculation zone was observed in 18 (35%) cases. Both of these flow types are commonly observed in human IAs. CONCLUSIONS: Most hemodynamic and geometric features in a commonly used elastase-induced rabbit saccular aneurysm model are qualitatively and quantitatively similar to those seen in large numbers of humancerebral aneurysms.
Authors: S Fukuda; N Hashimoto; H Naritomi; I Nagata; K Nozaki; S Kondo; M Kurino; H Kikuchi Journal: Circulation Date: 2000-05-30 Impact factor: 29.690
Authors: Zijing Zeng; David F Kallmes; Michael J Durka; Yonghong Ding; Debra Lewis; Ramanathan Kadirvel; Anne M Robertson Journal: J Biomech Eng Date: 2010-09 Impact factor: 2.097
Authors: Tor Ingebrigtsen; Michael K Morgan; Ken Faulder; Linda Ingebrigtsen; Trygve Sparr; Henrik Schirmer Journal: J Neurosurg Date: 2004-07 Impact factor: 5.115
Authors: David A Steinman; Jaques S Milner; Chris J Norley; Stephen P Lownie; David W Holdsworth Journal: AJNR Am J Neuroradiol Date: 2003-04 Impact factor: 3.825
Authors: S Lang; P Hoelter; A I Birkhold; M Schmidt; J Endres; C Strother; A Doerfler; H Luecking Journal: AJNR Am J Neuroradiol Date: 2019-09 Impact factor: 3.825
Authors: M J Gounis; I M J van der Bom; A K Wakhloo; S Zheng; J-Y Chueh; A L Kühn; A A Bogdanov Journal: AJNR Am J Neuroradiol Date: 2014-10-01 Impact factor: 3.825
Authors: Tobias Struffert; Sabine Ott; Markus Kowarschik; Frederik Bender; Edyta Adamek; Tobias Engelhorn; Philipp Gölitz; Stefan Lang; Charles M Strother; Arnd Doerfler Journal: Eur Radiol Date: 2012-08-16 Impact factor: 5.315