Literature DB >> 21270506

Genetic controls of Th17 cell differentiation and plasticity.

Chen Dong1.   

Abstract

CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naïve T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2 cells, several novel effector T cell subsets have been recently identified, including Th17 cells. There has been rapid progress in characterizing the development and function of Th17 cells. Here I summarize and discuss on the genetic controls of their differentiation and emerging evidence on their plasticity. This information may benefit understanding and treating immune diseases.

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Year:  2011        PMID： 21270506      PMCID： PMC3041933          DOI： 10.3858/emm.2011.43.1.007

Source DB:  PubMed          Journal:  Exp Mol Med        ISSN： 1226-3613            Impact factor:   8.718


  41 in total

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