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Literature DB >> 24831346

Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.

Michael Bonelli¹, Han-Yu Shih, Kiyoshi Hirahara, Kentner Singelton, Arian Laurence, Amanda Poholek, Tim Hand, Yohei Mikami, Golnaz Vahedi, Yuka Kanno, John J O'Shea.

Abstract

CD4(+) helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. We will also discuss the technological advances along with the attendant challenges presented by "big data," which allow the understanding of these processes on comprehensive scales.

Entities: Disease Gene

Mesh：

Substances：
Transcription Factors

Year: 2014 PMID： 24831346 PMCID： PMC4200396 DOI： 10.1007/82_2014_371

Source DB: PubMed Journal: Curr Top Microbiol Immunol ISSN： 0070-217X Impact factor: 4.291

342 in total

1. Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Authors: Cindy S Ma; Danielle T Avery; Anna Chan; Marcel Batten; Jacinta Bustamante; Stephanie Boisson-Dupuis; Peter D Arkwright; Alexandra Y Kreins; Diana Averbuch; Dan Engelhard; Klaus Magdorf; Sara S Kilic; Yoshiyuki Minegishi; Shigeaki Nonoyama; Martyn A French; Sharon Choo; Joanne M Smart; Jane Peake; Melanie Wong; Paul Gray; Matthew C Cook; David A Fulcher; Jean-Laurent Casanova; Elissa K Deenick; Stuart G Tangye
Journal: Blood Date: 2012-03-08 Impact factor: 22.113

2. STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function.

Authors: Roza I Nurieva; Andrew Podd; Yuhong Chen; Andrei M Alekseev; Mei Yu; Xiaopeng Qi; Hua Huang; Renren Wen; Junmei Wang; Haiyan S Li; Stephanie S Watowich; Hai Qi; Chen Dong; Demin Wang
Journal: J Biol Chem Date: 2012-02-08 Impact factor: 5.157

3. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.

Authors: Yukihiro Furusawa; Yuuki Obata; Shinji Fukuda; Takaho A Endo; Gaku Nakato; Daisuke Takahashi; Yumiko Nakanishi; Chikako Uetake; Keiko Kato; Tamotsu Kato; Masumi Takahashi; Noriko N Fukuda; Shinnosuke Murakami; Eiji Miyauchi; Shingo Hino; Koji Atarashi; Satoshi Onawa; Yumiko Fujimura; Trevor Lockett; Julie M Clarke; David L Topping; Masaru Tomita; Shohei Hori; Osamu Ohara; Tatsuya Morita; Haruhiko Koseki; Jun Kikuchi; Kenya Honda; Koji Hase; Hiroshi Ohno
Journal: Nature Date: 2013-11-13 Impact factor: 49.962

4. Regulatory T cells: stability revisited.

Authors: Samantha L Bailey-Bucktrout; Jeffrey A Bluestone
Journal: Trends Immunol Date: 2011-05-27 Impact factor: 16.687

5. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.

Authors: Ruoning Wang; Christopher P Dillon; Lewis Zhichang Shi; Sandra Milasta; Robert Carter; David Finkelstein; Laura L McCormick; Patrick Fitzgerald; Hongbo Chi; Joshua Munger; Douglas R Green
Journal: Immunity Date: 2011-12-23 Impact factor: 31.745

6. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation.

Authors: André Ballesteros-Tato; Beatriz León; Beth A Graf; Amy Moquin; Pamela Scott Adams; Frances E Lund; Troy D Randall
Journal: Immunity Date: 2012-03-29 Impact factor: 31.745

7. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

Authors: Ye Zheng; Steven Z Josefowicz; Arnold Kas; Tin-Tin Chu; Marc A Gavin; Alexander Y Rudensky
Journal: Nature Date: 2007-01-21 Impact factor: 49.962

8. Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells.

Authors: Karen W Makar; Mercedes Pérez-Melgosa; Maria Shnyreva; William M Weaver; David R Fitzpatrick; Christopher B Wilson
Journal: Nat Immunol Date: 2003-11-02 Impact factor: 25.606

9. Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

Authors: Takahisa Miyao; Stefan Floess; Ruka Setoguchi; Hervé Luche; Hans Joerg Fehling; Herman Waldmann; Jochen Huehn; Shohei Hori
Journal: Immunity Date: 2012-02-09 Impact factor: 31.745

10. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

Authors: Liang Zhou; Jared E Lopes; Mark M W Chong; Ivaylo I Ivanov; Roy Min; Gabriel D Victora; Yuelei Shen; Jianguang Du; Yuri P Rubtsov; Alexander Y Rudensky; Steven F Ziegler; Dan R Littman
Journal: Nature Date: 2008-03-26 Impact factor: 49.962

22 in total

Review 1. CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm.

Authors: Kiyoshi Hirahara; Toshinori Nakayama
Journal: Int Immunol Date: 2016-02-12 Impact factor: 4.823

Review 2. Epigenetic regulation of T helper cells and intestinal pathogenicity.

Authors: Yuya Hagihara; Yusuke Yoshimatsu; Yohei Mikami; Yoshiaki Takada; Shinta Mizuno; Takanori Kanai
Journal: Semin Immunopathol Date: 2019-03-19 Impact factor: 9.623

3. Diverse continuum of CD4⁺ T-cell states is determined by hierarchical additive integration of cytokine signals.

Authors: Inbal Eizenberg-Magar; Jacob Rimer; Irina Zaretsky; David Lara-Astiaso; Shlomit Reich-Zeliger; Nir Friedman
Journal: Proc Natl Acad Sci U S A Date: 2017-07-17 Impact factor: 11.205

4. Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4⁺ Th Cells.

Authors: Kaitlin A Read; Michael D Powell; Chandra E Baker; Bharath K Sreekumar; Veronica M Ringel-Scaia; Holly Bachus; R Emily Martin; Ian D Cooley; Irving C Allen; Andre Ballesteros-Tato; Kenneth J Oestreich
Journal: J Immunol Date: 2017-08-28 Impact factor: 5.422

5. Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells.

Authors: Giuseppe Sciumè; Yohei Mikami; Dragana Jankovic; Hiroyuki Nagashima; Alejandro V Villarino; Tasha Morrison; Chen Yao; Sadie Signorella; Hong-Wei Sun; Stephen R Brooks; Difeng Fang; Vittorio Sartorelli; Shingo Nakayamada; Kiyoshi Hirahara; Beatrice Zitti; Fred P Davis; Yuka Kanno; John J O'Shea; Han-Yu Shih
Journal: Immunity Date: 2020-10-02 Impact factor: 31.745

Review 10. Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans.

Authors: Federica Sallusto; Antonino Cassotta; Daniel Hoces; Mathilde Foglierini; Antonio Lanzavecchia
Journal: Cold Spring Harb Perspect Biol Date: 2018-03-01 Impact factor: 10.005