Literature DB >> 21268213

Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin.

K C Nicolaou1, Xuefeng Jiang, Peter J Lindsay-Scott, Andrei Corbu, Sawako Yamashiro, Andrea Bacconi, Velia M Fowler.   

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Year:  2011        PMID： 21268213      PMCID： PMC3139707          DOI： 10.1002/anie.201006780

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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Review 3.  Impact of natural products on developing new anti-cancer agents.

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4.  The absolute configuration of rhizopodin and its inhibition of actin polymerization by dimerization.

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5.  Effects of rhizopodin and latrunculin B on the morphology and on the actin cytoskeleton of mammalian cells.

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6.  Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells.

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Authors:  Scott E Denmark; Gregory L Beutner; Thomas Wynn; Martin D Eastgate
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9.  Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties.

Authors:  F Sasse; H Steinmetz; G Höfle; H Reichenbach
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Review 2.  Challenges and discoveries in the total synthesis of complex polyketide natural products.

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4.  An Effective Bifunctional Aldehyde Linchpin for Type II Anion Relay Chemistry: Development and Application to the Synthesis of a C16-C29 Fragment of Rhizopodin.

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Review 5.  Design and Synthesis of Simplified Polyketide Analogs: New Modalities beyond the Rule of 5.

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