Literature DB >> 22475318

Asymmetric total synthesis and absolute stereochemistry of the neuroactive marine macrolide palmyrolide A.

Rodolfo Tello-Aburto1, Emily M Johnson, Cheyenne K Valdez, William A Maio.   

Abstract

The first asymmetric total synthesis and determination of the absolute configuration for the neuroactive marine macrolide palmyrolide A is described. The highlight of the synthesis is macrocyclization via trans-enamide formation catalyzed by copper(I) iodide and cesium carbonate. Comparison with the authentic spectral data confirms the synthesis of (+)-ent-palmyrolide A.
© 2012 American Chemical Society

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Year:  2012        PMID： 22475318      PMCID： PMC3352666          DOI： 10.1021/ol300673m

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  36 in total

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