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Literature DB >> 212586

Comparison of initiation rates of encephalomyocarditis virus and host protein synthesis in infected cells.

Abstract

The relative initiation rates for encephalomyocarditis virus mRNA and host mRNA's in infected cells were measured using two independent techniques. In both cases the results showed that viral mRNA initiates at a much higher rate than host mRNA'S. This difference was observed midway in the infectious cycle, well before virus-induced cytopathic effects (leakage of low-molecular-weight metabolites, failure to exclude trypan blue) were apparent. These results confirm that encephalomyocarditis viral mRNA is a more efficient initiator than host mRNA's in vivo, as has previously been demonstrated in in vitro experiments.

Entities: Disease Species

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Year: 1978 PMID： 212586 PMCID： PMC525852

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

23 in total

1. Specificity of interferon action in protein synthesis.

Authors: P M Yau; T Godefroy-Colburn; C H Birge; T V Ramabhadran; R E Thach
Journal: J Virol Date: 1978-09 Impact factor: 5.103

2. Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus.

Authors: J B Flanegan; R F Petterson; V Ambros; N J Hewlett; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1977-03 Impact factor: 11.205

3. Selective translation of mengovirus RNA over Host mRNA in homologous, fractionated, cell-free translational systems from Ehrlich-ascites-tumor cells.

Authors: P B Hackett; E Egberts; P Traub
Journal: Eur J Biochem Date: 1978-02

4. Inhibition of translation by poliovirus: inactivation of a specific initiation factor.

Authors: J K Rose; H Trachsel; K Leong; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1978-06 Impact factor: 11.205

5. Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor.

Authors: F Golini; S S Thach; C H Birge; B Safer; W C Merrick; R E Thach
Journal: Proc Natl Acad Sci U S A Date: 1976-09 Impact factor: 11.205

6. Complete translation of encephalomyocarditis virus RNA and faithful cleavage of virus-specific proteins in a cell-free system from Krebs-2 cells.

Authors: Y V Svitkin; V I Agol
Journal: FEBS Lett Date: 1978-03-01 Impact factor: 4.124

7. Control of protein synthesis in extracts from poliovirus-infected cells. I. mRNA discrimination by crude initiation factors.

Authors: T Helentjaris; E Ehrenfeld
Journal: J Virol Date: 1978-05 Impact factor: 5.103

8. Rates of initiation of protein synthesis by two purified species of vesicular stomatitis virus messenger RNA.

Authors: H F Lodish; S Froshauer
Journal: J Biol Chem Date: 1977-12-25 Impact factor: 5.157

9. Maintenance of the ratio of alpha and beta globin synthesis in rabbit reticulocytes.

Authors: A G Stewart; M Lloyd; H R Arnstein
Journal: Eur J Biochem Date: 1977-11-01

10. Alteration of the intracellular energetic and ionic conditions by mengovirus infection of Ehrlich ascites tumor cells and its influence on protein synthesis in the midphase of infection.

Authors: E Egberts; P B Hackett; P Traub
Journal: J Virol Date: 1977-06 Impact factor: 5.103

18 in total

1. Specificity of interferon action in protein synthesis.

Authors: P M Yau; T Godefroy-Colburn; C H Birge; T V Ramabhadran; R E Thach
Journal: J Virol Date: 1978-09 Impact factor: 5.103

2. Specificity of protein synthesis inhibitors in the inhibition of encephalomyocarditis virus replication.

Authors: T V Ramabhadran; R E Thach
Journal: J Virol Date: 1980-04 Impact factor: 5.103

3. The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells.

Authors: J DeStefano; E Olmsted; R Panniers; J Lucas-Lenard
Journal: J Virol Date: 1990-09 Impact factor: 5.103

4. Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro.

Authors: D Etchison; S Fout
Journal: J Virol Date: 1985-05 Impact factor: 5.103

5. Evidence for the presence of an inhibitor on ribosomes in mouse L cells infected with mengovirus.

Authors: M N Pensiero; J M Lucas-Lenard
Journal: J Virol Date: 1985-10 Impact factor: 5.103

6. The adenovirus tripartite leader may eliminate the requirement for cap-binding protein complex during translation initiation.

Authors: P J Dolph; V Racaniello; A Villamarin; F Palladino; R J Schneider
Journal: J Virol Date: 1988-06 Impact factor: 5.103

Comparison of initiation rates of encephalomyocarditis virus and host protein synthesis in infected cells.

1. Specificity of interferon action in protein synthesis.

2. Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus.

3. Selective translation of mengovirus RNA over Host mRNA in homologous, fractionated, cell-free translational systems from Ehrlich-ascites-tumor cells.

4. Inhibition of translation by poliovirus: inactivation of a specific initiation factor.

5. Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor.

6. Complete translation of encephalomyocarditis virus RNA and faithful cleavage of virus-specific proteins in a cell-free system from Krebs-2 cells.

7. Control of protein synthesis in extracts from poliovirus-infected cells. I. mRNA discrimination by crude initiation factors.

8. Rates of initiation of protein synthesis by two purified species of vesicular stomatitis virus messenger RNA.

9. Maintenance of the ratio of alpha and beta globin synthesis in rabbit reticulocytes.

10. Alteration of the intracellular energetic and ionic conditions by mengovirus infection of Ehrlich ascites tumor cells and its influence on protein synthesis in the midphase of infection.

1. Specificity of interferon action in protein synthesis.

2. Specificity of protein synthesis inhibitors in the inhibition of encephalomyocarditis virus replication.

3. The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells.

4. Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro.

5. Evidence for the presence of an inhibitor on ribosomes in mouse L cells infected with mengovirus.

6. The adenovirus tripartite leader may eliminate the requirement for cap-binding protein complex during translation initiation.

7. Encephalomyocarditis viral RNA can be translated under conditions of poliovirus-induced translation shutoff in vivo.

8. Discriminatory inhibition of protein synthesis in cell-free systems by vaccinia virus transcripts.

9. Translational elongation rate changes in encephalomyocarditis virus-infected and interferon-treated cells.

10. Inhibition of host translation in encephalomyocarditis virus-infected L cells: a novel mechanism.