Literature DB >> 184455

Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor.

F Golini, S S Thach, C H Birge, B Safer, W C Merrick, R E Thach.   

Abstract

Encephalomyocarditis viral RNA has previously been shown to outcompete host cellular mRNA has for translation in vitro in crude and fractionated protein synthesizing systems. In the present communication it is shown that the competition is regulated by an initiation factor or complex of factors, and not the 40S initiation complex per se. The factor primarily involved is the murine equivalent of a component present in a partially purified preparation of rabbit initiation factor M3. Both the murine and rabbit factors are clearly messenger discriminatory.

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Year:  1976        PMID： 184455      PMCID： PMC430920          DOI： 10.1073/pnas.73.9.3040

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  A protein binding the methylated 5'-terminal sequence, m7GpppN, of eukaryotic messenger RNA.

Authors:  W Filipowicz; Y Furuichi; J M Sierra; S Muthukrishnan; A J Shatkin; S Ochoa
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

2.  Nonribosomal proteins associated with eukaryotic native small ribosomal subunits.

Authors:  C Freienstein; G Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

3.  Evidence for role of m7G5'-phosphate group in recognition of eukaryotic mRNA by initiation factor IF-M3.

Authors:  D A Shafritz; J A Weinstein; B Safer; W C Merrick; L A Weber; E D Hickey; C Baglioni
Journal:  Nature       Date:  1976-05-27       Impact factor: 49.962

4.  Specificity in initiation of protein synthesis in a fractionated mammalian cell-free system.

Authors:  D T Wigle; A E Smith
Journal:  Nat New Biol       Date:  1973-04-04

5.  Model for the regulation of mRNA translation applied to haemoglobin synthesis.

Authors:  H F Lodish
Journal:  Nature       Date:  1974-10-04       Impact factor: 49.962

6.  Initiation of eukaryotic protein synthesis: (Met-tRNA f -40S ribosome) initiation complex catalysed by purified initiation factors in the absence of mRNA.

Authors:  M H Schreier; T Staehelin
Journal:  Nat New Biol       Date:  1973-03-14

7.  5'-terminal structure of poliovirus polyribosomal RNA is pUp.

Authors:  M J Hewlett; J K Rose; D Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205

8.  The 5' end of poliovirus mRNA is not capped with m7G(5')ppp(5')Np.

Authors:  A Nomoto; Y F Lee; E Wimmer
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205

9.  Discrimination between messenger ribonucleic acids by a mammalian translation initiation factor.

Authors:  U Nudel; B Lebleu; M Revel
Journal:  Proc Natl Acad Sci U S A       Date:  1973-07       Impact factor: 11.205

10.  Encephalomyocarditis virus infection of mouse plasmacytoma cells. I. Inhibition of cellular protein synthesis.

Authors:  C Lawrence; R E Thach
Journal:  J Virol       Date:  1974-09       Impact factor: 5.103
  10 in total
  32 in total

1.  mRNP proteins, initiation factors and phosphorylation.

Authors:  J M Egly; R Elkaim; M Pierre
Journal:  Mol Biol Rep       Date:  1979-05-31       Impact factor: 2.316

2.  Specificity of interferon action in protein synthesis.

Authors:  P M Yau; T Godefroy-Colburn; C H Birge; T V Ramabhadran; R E Thach
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

3.  Comparison of initiation rates of encephalomyocarditis virus and host protein synthesis in infected cells.

Authors:  G Jen; C H Birge; R E Thach
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

4.  Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virus.

Authors:  M Niepmann; A Petersen; K Meyer; E Beck
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

5.  Degradation of cellular mRNA during infection by herpes simplex virus.

Authors:  Y Nishioka; S Silverstein
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

6.  Inhibition of translation by poliovirus: inactivation of a specific initiation factor.

Authors:  J K Rose; H Trachsel; K Leong; D Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

7.  Specificity of protein synthesis inhibitors in the inhibition of encephalomyocarditis virus replication.

Authors:  T V Ramabhadran; R E Thach
Journal:  J Virol       Date:  1980-04       Impact factor: 5.103

8.  Control of protein synthesis in extracts from poliovirus-infected cells. I. mRNA discrimination by crude initiation factors.

Authors:  T Helentjaris; E Ehrenfeld
Journal:  J Virol       Date:  1978-05       Impact factor: 5.103

9.  Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro.

Authors:  D Etchison; S Fout
Journal:  J Virol       Date:  1985-05       Impact factor: 5.103

10.  Translational control of protein synthesis after infection by vesicular stomatitis virus.

Authors:  H F Lodish; M Porter
Journal:  J Virol       Date:  1980-12       Impact factor: 5.103
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